Table 1 General characteristics, biochemical laboratory data, genotypes, and alleles frequencies
Normal weight | Obese subject | P valuea | |
|---|---|---|---|
Media (95% CI) | Media (95% CI) | (obese vs. normal weight) | |
Age (years) | 39 (36.7–41.1) | 43 (40.7–45.8) | 0.018 |
Sex | |||
M | 14 | 19 | 0.194b |
F | 50 | 44 | |
BMI (kg/m2) | 23 | 33 | <0.001 |
Systolic (mm Hg) | 115 (110.6–118.9) | 127 (121.5–131.9) | <0.001 |
Diastolic (mm Hg) | 71 (68.5–73.3) | 76 (72.8–79.0) | 0.012 |
Glucose (mg/dl) | 73 (71.0–75.9) | 85 (76.7–92.4) | 0.012 |
TG (mg/dl) | 112 (95.7–127.9) | 168 (146.7–189.5) | <0.001 |
TC (mg/dl) | 177 (169.6–184.7) | 199 (190.9–206.4) | <0.001 |
HDL-C (mg/dl) | 50 (46.6–52.5) | 43 (40.2–45.0) | <0.001 |
LDL-C (mg/dl) | 109 (102.1–114.8) | 128 (121.7–134.0) | <0.001 |
VLDL-C (mg/dl) | 23 (29.9–26.1) | 31 (28.1–34.6) | <0.001 |
Insulin (mg/dl) | 8 (6.9–8.6) | 17 (14.7–18.9) | <0.001 |
Paraoxonase activity (nmol/min/ml) | 177 (137.0–217.8) | 172 (122.3–221.3) | 0.858 |
Arylesterase activity (μmol/min/ml) | 70 (49.3–90.0) | 71.0 (47.8–94.8) | 0.964 |
Frequency (%) | Frequency (%) | ||
|---|---|---|---|
PON1-L55M genotype | |||
LL | 65.6 | 81 | 0.032b |
LM | 26.6 | 19 | |
MM | 7.8 | 0 | |
Allele L frequency | 78.9 | 90.5 | 0.0075b |
Allele M frequency | 20.8 | 9.5 | |
PON1-Q192R genotype | |||
31.3 | 28.6 | 0.944b | |
QR | 35.9 | 38.1 | |
RR | 32.8 | 33.1 | |
Allele Q frequency | 49.2 | 47.6 | 0.989b |
Allele R frequency | 50.7 | 52.4 | |