Fig. 1
From: Why tocotrienols work better: insights into the in vitro anti-cancer mechanism of vitamin E
Schematic representation of the proposed relationship between uptake (cell content) and biological responsiveness to T3 treatment in vitro. T3 recruit different responses in cancer and non-cancer cells that range from cytoprotection to anti-cancer pro-apoptotic effects. The cell content of T3 appears to drive these responses through the modulation of different signaling pathways and groups of genes that link in a functional continuity the concentration-dependent and time-dependent responses to T3. Further details are reported in the text