Table 1 Common HDAC, HAT and DNMT modulators derived from natural sources

HDAC

 Allyl mercaptan

Nian et al. (2008)

 Amamistatin

Fennell and Miller (2007)

 Apicidin

Darkin-Rattray et al. (1996)

 Azumamide E

Maulucci et al. (2007)

 Caffeic acid

Waldecker et al. (2008)

 Chlamydocin

Brosch et al. (1995)

 Chlorogenic acid

Bora-Tatar et al. (2009)

 Cinnamic acid

Bora-Tatar et al. (2009)

 Coumaric/hydroxycinnamic acid

Waldecker et al. (2008)

 Curcumin

Bora-Tatar et al. (2009)

 Depudecin

Kwon et al. (1998)

 Diallyl disulfide

Lea et al. (1999)

 Equol

Hong et al. (2004)

 Flavone

Bontempo et al. (2007)

 Genistein

Kikuno et al. (2008)

 Histacin

Haggarty et al. (2003)

 Isothiocyanates

Ma et al. (2006)

 Largazole

Ying et al. (2008)

 Pomiferin

Son et al. (2007)

 Psammaplin

Pina et al. (2003)

 SAHA (Vorinostat)

Richon et al. (1998)

 S-allylmercaptocysteine

Lea et al. (2002)

 Sulforaphane

Myzak et al. (2004)

 Trapoxin

(Kijima et al. 1993)

 Ursolic acid

Chen et al. (2009)

 Zerumbone

Chung et al. (2008)

HAT

 Allspice

Lee et al. (2007)

 Anarcardic acid

Balasubramanyam et al. (2003), Ghizzoni et al. (2010)

 EGCG

Choi et al. (2009a)

 Curcumin

Balasubramanyam et al. (2004), Marcu et al. (2006)

 Gallic acid

Choi et al. (2009b)

 Garcinol

Balasubramanyam et al. (2004)

 Quercetin

Ruiz et al. (2007)

 Sanguinarine

Selvi et al. (2009)

 Plumbagin

Ravindra et al. (2009)

DNMT

 Genistein

Day et al. (2002)

 EGCG

Fang et al. (2003)

 Psammaplins

Pina et al. (2003)

 Quercetin, fisetin, myricetin

Lee et al. (2005)

 Caffeic acid

Lee and Zhu (2006)

 Chlorogenic acid

Lee and Zhu (2006)

 Curcumin

Moiseeva et al. (2007)

 Parthenolide

Liu et al. (2009)

 Mahanine

Sheikh et al. (2010)