Table 3 Regulation of MMP transcription by IL1β and CSE in primary chondrocytes

MMP-1

PC1

1.00 ± 0.10

5.76 ± 0.26*

1.83 ± 0.03**

0.91 ± 0.07**

0.78 ± 0.06**

PC2

1.00 ± 0.18

15.4 ± 0.01*

10.12 ± 0.45**

2.21 ± 0.22**

0.91 ± 0.10**

PC3

1.00 ± 0.15

4.24 ± 0.28*

3.63 ± 0.18

3.10 ± 0.06**

1.27 ± 0.09**

MMP-2

PC1

1.00 ± 0.06

1.46 ± 0.06*

1.05 ± 0.09**

0.97 ± 0.05**

0.83 ± 0.02**

PC2

1.00 ± 0.02

1.17 ± 0.05

1.08 ± 0.15

1.06 ± 0.13

0.82 ± 0.02

PC3

1.00 ± 0.09

1.24 ± 0.03

1.23 ± 0.04

1.55 ± 0.08**

1.06 ± 0.08

MMP-3

PC1

1.00 ± 0.01

3.16 ± 0.01*

1.35 ± 0.02**

1.08 ± 0.01**

0.84 ± 0.01**

PC2

1.00 ± 0.01

8.37 ± 0.25*

3.71 ± 0.09**

1.12 ± 0.01**

1.05 ± 0.04**

PC3

1.00 ± 0.01

4.74 ± 0.02*

3.12 ± 0.02**

3.48 ± 0.02**

1.15 ± 0.01**

MMP-7

PC1

1.00 ± 0.46

10.40 ± 1.06*

5.56 ± 0.92**

1.97 ± 1.60**

3.41 ± 0.02**

PC2

1.00 ± 0.47

8.19 ± 0.26*

2.41 ± 0.27**

3.15 ± 1.33**

2.14 ± 0.82**

PC3

1.00 ± 0.19

4.45 ± 0.17*

3.02 ± 0.12**

2.78 ± 0.06**

3.04 ± 0.11**

MMP-8

PC1

1.00 ± 0.57

1.29 ± 0.02

1.92 ± 0.22

0.65 ± 0.35

1.32 ± 0.58

PC2

1.00 ± 0.06

2.11 ± 0.33*

1.69 ± 0.35

1.02 ± 0.02**

0.57 ± 0.11**

PC3

1.00 ± 0.02

1.44 ± 0.13

1.14 ± 0.03

2.04 ± 0.26

0.89 ± 0.17

MMP-9

PC1

1.00 ± 0.01

1.89 ± 0.28*

1.11 ± 0.04**

0.85 ± 0.16**

1.03 ± 0.10**

PC2

1.00 ± 0.04

10.29 ± 1.28*

2.64 ± 0.36**

0.66 ± 0.16**

0.54 ± 0.06**

PC3

1.00 ± 0.37

7.65 ± 1.48*

3.76 ± 1.15**

1.22 ± 0.14**

2.15 ± 0.18**

MMP-13

PC1

1.00 ± 0.17

13.22 ± 0.07*

1.39 ± 0.03**

0.72 ± 0.04**

0.64 ± 0.05**

PC2

1.00 ± 0.01

10.42 ± 0.37*

2.71 ± 0.23**

1.11 ± 0.03**

0.85 ± 0.01**

PC3

1.00 ± 0.02

4.65 ± 0.40*

2.80 ± 0.24**

4.42 ± 0.54

1.20 ± 0.01**