Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations

Table 2 Genes upregulated by benfotiamine

Symbol	Acc	Description	FC NG	FC HG
SERPINB7	NM_003784	Serpin peptidase inhibitor, clade B (ovalbumin), member 7	3.39	2.27
MX1	NM_002462	Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	3.19	3.32*
CPA4	NM_016352	Carboxypeptidase A4	3.16	1.57*
TM4SF4	NM_004617	Transmembrane 4 L six family member 4	3.11	2.14*
LCE3D	NM_032563	Late cornified envelope 3D	2.76	2.54
IFI44L	NM_006820	Interferon-induced protein 44-like	2.62	2.54
PSG4	NM_213633	Pregnancy specific beta-1-glycoprotein 4	2.43	1.98
TSGA10	NM_182911	Testis specific, 10	2.38	2.55
NRXN2	NM_138732	Neurexin 2	2.32	1.95
MT1G	NM_005950	Metallothionein 1G	2.32	1.44
CCL26	NM_006072	Chemokine (C–C motif) ligand 26	2.18	1.60*
HCG_1815504	XM_498560	HCG1815504	2.15	1.85*
BRE	NM_199193	Brain and reproductive organ-expressed (TNFRSF1A modulator)	2.12	1.79
PSG11	NM_002785	Pregnancy specific beta-1-glycoprotein 11	2.11	1.42*
TFPI	NM_001032281	Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	2.10	1.40*
EVI2A	NM_001003927	Ecotropic viral integration site 2A	2.10	1.69*
ALDH3A1	NM_000691	Aldehyde dehydrogenase 3 family. memberA1	2.09	2.13
FGGY	NM_001113411	FGGY carbohydrate kinase domain containing	2.02	1.95
DEFB103B	NM_001081551	Defensin, beta 103B	2.01	1.27*
IFI44	NM_006417	Interferon-induced protein 44	1.98	2.07*

[20 genes with greatest fold change (FC) increased after benfotiamine treatment (200 μM, 4 days) as compared to cells not exposed to benfotiamine under NG conditions, with corresponding values under HG conditions], adjusted P value < 0.1
*Adjusted P value ≥ 0.1. N = 3 in each group

ISSN: 1865-3499