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Fig. 2 | Genes & Nutrition

Fig. 2

From: Impact of butyrate on PKM2 and HSP90β expression in human colon tissues of different transformation stages: a comparison of gene and protein data

Fig. 2

Impact of clinical parameters on PKM2 gene expression in normal and malignant colon tissue. Total RNA from paired normal, adenoma, and tumor colon tissues (filled circle) was quantified by qPCR and compared to diverse clinical data by Spearman correlation analysis. Twenty patients in total were investigated, whereby only 4 of them had all three tissue types. Trends and significant outcomes are presented. a In cancer tissue, an up-regulation of PKM2 mRNA was observed with progress of dedifferentiation indicated by the tumor grading. The dotted line denotes no expression changes (fold change 1). b In normal colon tissue, PKM2 mRNA expression went down with increasing age of patients

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Genes & Nutrition

ISSN: 1865-3499

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