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Table 4 Cellular uptake of PPs reported for different cell lines

From: Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations

PP

Test conc. (μM)

Incubation time

Cell line

Intracellular conc.

Study

Apigenin

50

2 h

Caco-2

~1.2 nmol/mg protein

Yokomizo and Moriwaki (2006)a

Kaempferol

~1.8 nmol/mg protein

Luteolin

~1.3 nmol/mg protein

Quercetin

~0.9 nmol/mg protein

Myricetin

ND

Myricetrin

ND

Rutin

ND

Isoquercitrin

ND

Quercetin

500

1 h

H4IIE

33.4 nmol/106 cells

Watjen et al. (2005)

Fisetin

12.67 nmol/106 cells

Myricetin

0.22 nmol/106 cells

Morin

2.35 nmol/106 cells

Taxifolin

0.2 nmol/106 cells

Rutin

0

Catechin

0

EC

50

1 h

Caco-2

0

Vaidyanathan and Walle (2003)a

(+)-Catechin

~150 pmol/mg protein

ECG

~3,000 pmol/mg protein

EGCG

~2,400 pmol/mg protein

Quercetin

5

30 min

HepG2

~900 pmol/mg protein

Boulton et al. (1999)a

  1. ND not detected
  2. PP polyphenols
  3. aData were estimated from graphs