Table 5 Correlation of serum Se and TR activity by genotype of six selenoprotein genes
Gene | SNP | Genotype | N | serum Se (ng/ml) | TR Activity | Correlation | ||
|---|---|---|---|---|---|---|---|---|
Mean (SD) | Range | Mean (SD) | Range | |||||
GPx1 | rs1050450 | C/C | 243 | 112.1 (1.2) | 72.6–181.6 | 1.10 (0.79) | 0–3.15 | r = 0.189, P = 0.003 |
C/T | 219 | 110.7 (1.2) | 63.2–195.0 | 1.08 (0.74) | 0–3.78 | r = 0.110, P = 0.105 | ||
T/T | 40 | 111.2 (1.2) | 64.0–222.7 | 0.88 (0.75) | 0–2.57 | r = 0.258, P = 0.109 | ||
SELS | rs28665122 | A/A | 7 | 92.6 (1.1) | 75.8–102.6 | 0.76 (0.53) | 0–1.37 | r = 0.258, P = 0.577 |
A/G | 87 | 108.2 (1.2) | 75.8–157.9 | 1.01 (0.67) | 0–3.15 | r = 0.004, P = 0.970 | ||
G/G | 275 | 108.5 (1.2) | 65.5–157.9 | 1.00 (0.77) | 0–3.78 | r = 0.137, P = 0.023 | ||
SEPP1 | rs3877899 | A/A | 24 | 107.1 (1.3) | 75.8–195.0 | 1.10 (0.70) | 0–2.36 | r = 0.087, P = 0.688 |
A/G | 189 | 109.7 (1.2) | 63.2–170.5 | 1.10 (0.76) | 0–3.78 | r = 0.063, P = 0.384 | ||
G/G | 285 | 113.0 (1.2) | 65.5–222.7 | 1.06 (0.78) | 0–3.68 | r = 0.224, P = 0.0001 | ||
SELS | rs4965373 | A/A | 57 | 112.2 (1.2) | 79.0–195.0 | 1.30 (0.81) | 0–2.68 | r = 0.201, P = 0.137 |
A/G | 213 | 113.0 (1.2) | 64.0–222.7 | 1.01 (0.75) | 0–3.68 | r = 0.199, P = 0.004 | ||
G/G | 232 | 109.8 (1.2) | 63.2–195.0 | 1.08 (0.76) | 0–3.78 | r = 0.108, P = 0.104 | ||
SEP15 | rs5845 | C/C | 315 | 111.1 (1.2) | 63.2–22.7 | 1.06 (0.76) | 0–3.78 | r = 0.120, P = 0.068 |
C/T | 172 | 111.9 (1.2) | 72.6–195.0 | 1.08 (0.76) | 0–3.26 | r = 0.148, P = 0.053 | ||
T/T | 15 | 114.0 (1.2) | 75.8–157.9 | 1.42 (0.82) | 0–3.05 | r = 0.167, P = 0.029 | ||
GPx4 | rs713041 | C/C | 156 | 111.9 (1.2) | 72.6–157.9 | 1.12 (0.80) | 0–3.68 | r = −0.020, P = 0.944 |
C/T | 241 | 110.4 (1.2) | 63.2–222.7 | 1.10 (0.72) | 0–3.26 | r = 0.184, P = 0.004 | ||
T/T | 105 | 113.3 (1.2) | 79.0–195.0 | 0.95 (0.81) | 0–3.78 | r = 0.204, P = 0.037 | ||