Table 7 Correlation of serum Se and peroxide-challenged DNA damage, by genotype of six selenoprotein genes
Gene | SNP | Genotype | N | serum Se (ng/ml) | DNA damage with peroxide challenge | Correlation | ||
|---|---|---|---|---|---|---|---|---|
Mean (SD) | Range | Mean (SD) | Range | |||||
GPx1 | rs1050450 | C/C | 243 | 112.1 (1.2) | 72.6–181.6 | 7.59 (1.86) | 3.28–14.78 | r = 0.089, P = 0.169 |
C/T | 219 | 110.7 (1.2) | 63.2–195.0 | 7.47 (1.65) | 4.35–13.19 | r = 0.024, P = 0.731 | ||
T/T | 40 | 111.2 (1.2) | 64.0–222.7 | 7.63 (1.86) | 2.97–11.74 | r = 0.184, P = 0.255 | ||
SELS | rs28665122 | A/A | 7 | 92.6 (1.1) | 75.8–102.6 | 7.49 (0.73) | 6.52–8.44 | r = −0.553, P = 0.198 |
A/G | 87 | 108.2 (1.2) | 75.8–157.9 | 7.66 (1.62) | 4.74–13.22 | r = 0.043, P = 0.692 | ||
G/G | 275 | 108.5 (1.2) | 65.5–157.9 | 7.32 (1.73) | 2.97–13.27 | r = −0.050, P = 0.412 | ||
SEPP1 | rs3877899 | A/A | 24 | 107.1 (1.3) | 75.8–195.0 | 7.47 (2.14) | 2.97–11.29 | r = 0.173, P = 0.429 |
A/G | 189 | 109.7 (1.2) | 63.2–170.5 | 7.42 (1.89) | 4.46–14.69 | r = 0.061, P = 0.406 | ||
G/G | 285 | 113.0 (1.2) | 65.5–222.7 | 7.64 (1.66) | 3.28–14.78 | r = 0.065, P = 0.275 | ||
SELS | rs4965373 | A/A | 57 | 112.2 (1.2) | 79.0–195.0 | 7.52 (1.80) | 4.35–13.19 | r = −0.061, P = 0.656 |
A/G | 213 | 113.0 (1.2) | 64.0–222.7 | 7.55 (1.66) | 4.46–14.78 | r = 0.201, P = 0.003 | ||
G/G | 232 | 109.8 (1.2) | 63.2–195.0 | 7.53 (1.87) | 2.97–14.69 | r = −0.003, P = 0.969 | ||
SEP15 | rs5845 | C/C | 315 | 111.1 (1.2) | 63.2–222.7 | 7.51 (1.70) | 2.97–14.78 | r = 0.061, P = 0.281 |
C/T | 172 | 111.9 (1.2) | 72.6–195.0 | 7.63 (1.88) | 4.35–14.69 | r = 0.102, P = 0.188 | ||
T/T | 15 | 114.0 (1.2) | 75.8–157.9 | 7.08 (1.91) | 5.01–10.81 | r = −0.028, P = 0.924 | ||
GPx4 | rs713041 | C/C | 156 | 111.9 (1.2) | 72.6–157.9 | 7.48 (1.80) | 3.84–14.78 | r = 0.044, P = 0.591 |
C/T | 241 | 110.4 (1.2) | 63.2–222.7 | 7.58 (1.74) | 4.35–13.23 | r = 0.051, P = 0.433 | ||
T/T | 105 | 113.3 (1.2) | 79.0–195.0 | 7.54 (1.81) | 2.97–13.22 | r = 0.177, P = 0.077 | ||