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Table 8 Key tissue changes in gene expression in response to a dietary iron deficiency potentially contributing to a pro-lipogenic phenotype

From: Enhanced expression of lipogenic genes may contribute to hyperglycemia and alterations in plasma lipids in response to dietary iron deficiency

Gene

Liver

Skeletal muscle

Function

SREBF1

↑

↑

Lipogenesis

FASN

↑

NC

β-oxidation

CPT1A

↓

↓

β-oxidation

CPT2

↓

↓

β-oxidation

ACAD10

↓

↓

β-oxidation

HMGCS2

↓

↓

Ketogenesis

ACO2

↓

↓

TCA Cycle

PFKL

↑

↑

Glycolysis

PDK4

↑

↓

Gluconeogenesis

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Genes & Nutrition

ISSN: 1865-3499

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