Fig. 4

Effect of 10 and 25 μmol/l AITC on MT2 (a) mRNA level in Huh7 cells. Data are means + SEM, n = 6. Asterisk (*) indicates significant differences between untreated controls and AITC-treated cells; Effect of AITC and APOE genotype on hepatic metallothionein 1 (MT1; b) and metallothionein 2 (MT2; c) and Nrf1 (d) mRNA levels determined by real-time PCR in APOE3 (open bars) as compared to APOE4 mice (solid bars) fed with and without 15 mg AITC/kg body weight. Values are means + SEM, n = 6 (study 2). Means without a common letter significantly differ, p < 0.05