Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat

Table 3 The association of T2D-GPS with change in insulin sensitivity (Si), insulin secretion (AIRg) and disposition index (DI) in response to the dietary interventions to lower saturated fat intake

	Per allele effect of T2D-GPS on change in trait on the reference diet			Per allele effect of T2D-GPS on change in trait on the High MUFA/high GI diet			Per allele effect of T2D-GPS on change in trait on the High MUFA/low GI diet			Per allele effect of T2D-GPS on change in trait on the Low fat/high GI diet			Per allele effect of T2D-GPS on change in trait on the Low fat/low GI diet			Global test of diet
	Effect	SE	P	Effect	SE	P	Effect	SE	P	Effect	SE	P	Effect	SE	P	P
Change in insulin sensitivity (Si)	0.00	0.02	0.93	0.00	0.02	0.92	−0.03	0.02	0.11	−0.02	0.01	0.16	0.02	0.02	0.19	0.24
Change in insulin secretion (AIRg)	−0.02	0.03	0.58	−0.02	0.02	0.44	−0.02	0.02	0.31	−0.01	0.02	0.46	−0.01	0.02	0.46	0.99
Change in disposition index (DI)	−0.02	0.03	0.63	−0.01	0.02	0.58	−0.04	0.02	0.05	−0.03	0.02	0.14	0.00	0.02	0.87	0.61

Data are presented as per allele effect size of T2D-GPS on the change in trait by each dietary intervention group, derived from the coefficient, standard error and P value of the T2D-GPS (reference) and T2D-GPS + interaction terms for each diet group from linear regression models. The models were of T2D-GPS against change in Si, AIRg or DI, adjusted for baseline measure, age, gender, BMI, centre, weight change and diet group and T2D-GPS × diet group. Data for Si, AIRg and DI were log(n)-transformed for analysis and are presented in this form

ISSN: 1865-3499