Table 1 Clinical severity score (CSS) changes following 6-month ω-3 PUFAs supplementation in stage I RTT patients (individual items)
From: Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil
Clinical manifestation | Severity Score | P value | |
|---|---|---|---|
Before ω-3 PUFAs supplementation | After ω-3 PUFAs supplementation (6 months) | ||
Age of onset of regression | 4 [4–4] | 4 [4–4] | 1.0 |
Somatic growth | 1.5 [1–2] | 1 [1–2] | 0.8182 |
Head growth | 3 [3–3] | 3 [3–3] | 1.0 |
Motor/independent sitting | 4 [4–4] | 0 [0–1] | 0.0087 |
Ambulation | 5 [5–5] | 1 [1–4] | 0.0152 |
Hand use | 4 [4–4] | 2 [2–2] | 0.0022 |
Scoliosis | 0 [0–0] | 0 [0–0] | 1.0 |
Language | 4 [4–4] | 3 [3–4] | 0.0649 |
Nonverbal communication | 5 [5–5] | 0 [0–1] | 0.0022 |
Respiratory dysfunction | 4 [4–4] | 1 [0–1] | <0.0001 |
Autonomic symptoms | 0 [0–0] | 0 [0–0] | 1.0 |
Onset of stereotypies | 4 [4–4] | 4 [4–4] | 1.0 |
Epilepsy/seizures | 0 [0–0] | 0 [0–0] | 1.0 |