Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype

Table 2 Top SNPs associated with the equol-producing phenotype (p value <1 × 10⁻⁵)

Chromosome	SNP rsID^a	Base pair	Location	Minor allele	Odds ratio	95 % confidence interval		P ^b	TFBS^c
Chromosome	SNP rsID^a	Base pair	Location	Minor allele	Odds ratio	Lower	Upper	P ^b	Major allele	Minor allele
6	rs6927608	105394818	Intron 2	C	0.5715	0.4527	0.7215	2.5 × 10⁻⁶
6	rs4946645	105402228	Intron 1	G	0.5774	0.4586	0.7271	3.0 × 10⁻⁶		C/EBPb
6	rs11759010	105342995	Intron 9	G	0.5784	0.4586	0.7295	3.8 × 10⁻⁶		CRE-BP
6	rs17065302	105336339	Intron 10	G	0.5805	0.4598	0.7328	4.8 × 10⁻⁶	AP1
6	rs4245525	105412837	5′ upstream	T	0.5868	0.4644	0.7414	7.9 × 10⁻⁶

^aAll of the five associated SNPs are located in a LD block (r ² > 0.95)
^bLogistic regression analysis, controlling for cohort, sex, and age as covariates
^cTFBS: Predicted transcription factor binding sites analyzed by TFSEARCH

ISSN: 1865-3499