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Fig. 7 | Genes & Nutrition

Fig. 7

From: Growth factor TGF-β induces intestinal epithelial cell (IEC-6) differentiation: miR-146b as a regulatory component in the negative feedback loop

Fig. 7

Schematic illustration of miR-146b function in IEC-6 cells mediating TGF-β signaling. It is known that the stimulatory Smad2/3 form complex with Smad4 as an immediate consequence of TGF-β stimuli; up-regulation of miR-146b (involving ERK1/2 activation) directly causes the abundance of SIAH2 functional protein to decrease, which releases of the inhibitory Smad7 to negatively regulate the activities of stimulatory Smads, thus maintaining the homeostasis of TGF-β signaling pathway

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Genes & Nutrition

ISSN: 1865-3499

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