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Table 3 Leading-edge subsets of genes found in down-regulated GO terms obtained in functional enrichment analysis of microarray data using GSEA

From: Effect of rosemary polyphenols on human colon cancer cells: transcriptomic profiling and functional enrichment analysis

Functional group

HT29

SW480

Gene set (GO term)

Leading-edge subsets of genesa

Gene set (GO term)

Leading-edge subsets of genesa

Cytokinesis

Cell division, cytokinesis

SEPT4, SEPT6, SEPT7, BRCA2, PRC1, RACGAP1, ANLN, NUSAP1

Cell division, cytokinesis

INCENP, PRC1, DIAPH2, BRCA2, RACGAP1, SEPT6, MYH10, BIRC5, NUSAP1

Chromosome segregation

Sister chromatid segregation, Mitotic sister chromatid segregation, chromosome segregation, chromosome organization and biologenesis

NUSAP1, CDC23, PDS5B, ZWINT, ESPL1, NDC80, NCAPH, PAM, CENPE, SMC4

Sister chromatid segregation, Mitotic sister chromatid segregation, chromosome segregation

PAM, NCAPH, CENPE, ESPL1, NDC80, SMC4, SMC1A, NUSAP1

M phase of mitotic cell cycle

Cell cycle process, cell cycle phase, mitotic cell cycle, mitosis, M phase of mitotic cell, M phase, cell cycle

TTK, KIF2C, KIF11, CCNA2, PML, MAD2L1, BUB1, KNTC1, AURKA, NEK2, TPX2, CIT, PLK1, KIF15, NUSAP1, ZWINT, ESPL1, NDC80, NCAPH, PAM, CENPE, SMC4

Mitosis, M phase of mitotic cell

PAM, NCAPH, CENPE, ESPL1, NDC80, SMC4, SMC1A, BIRC5, KNTC1, TTK, AURKA, KIF2C, BUB1, PBRM1, CCNA2, KIF11, KIF15, TPX2, SMC3, MAD2L1, PLK1, CIT

RNA processing

RNA processing, RNA splicing

PPARGC1A, SFRS6, NONO, SFRS7, SFRS1, SFRS2, SFRS11, CWC15, PRPF31, SRPK2, SF3B3, USP39, SFPQ, TXNL4A, SNRPD1, SMNDC1, EFTUD2, SLU7, SNW1, TRA2A, SFRS2IP

  

DNA repair

Double strand DNA repair, DNA repair, response to DNA damage stimulus

MRE11A, RAD54B, RAD51, RAD21, POLA1

  
  1. aBold: genes with adjusted p value <0.05