Fig. 2
From: Current status on genome–metabolome-wide associations: an opportunity in nutrition research
a Manhattan plot resulting from a GWAS that uses as input phenotype the intensity in 1H-NMR chemical shift centered at 2.856 ppm. This chemical shift peak has been assigned to Trimethyl-amine. The plot shows a strong association with a series of SNPs on chromosome 10. These SNPs are located in or around the gene PYROXD2, which encodes a probable pyridine nucleotide-disulfide oxidoreductase. b QQ-plot corresponding to the Manhattan plot shown in subfigure (a). The plot underlines the significance of the association and indicates that the strength of the association is not driven by lambda inflation