Obesity polymorphisms identified in genome-wide association studies interact with n-3 polyunsaturated fatty acid intake and modify the genetic association with adiposity phenotypes in Yup’ik people

Table 5 Interaction with n-3 PUFA intake modifies the GRS association with adiposity phenotypes

Outcome	Main effect^a	GRS*n-3 PUFA intake^b	GRS*community group^c
BMI (kg/m²)	0.012	0.011	0.480
Percentage body fat (%)	0.022	0.025	0.469
Hip circumference (cm)	0.08	0.068	0.916
Thigh circumference (cm)	0.025	0.084	0.555
Waist circumference (cm)	0.038	0.018	0.517

Results significant at p ≤ 0.05 are highlighted in bold
^a p values for GRS analysis adjusted for sex, age, community group, and n-3 PUFA intake
^b p values for interaction analysis (GRS*n-3 PUFA) adjusted for sex, age, community group, and n-3 PUFA intake
^c p values for interaction analysis (GRS*community group) adjusted for sex, age, community group, and n-3 PUFA intake

ISSN: 1865-3499