Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort

Table 3 Genetic variants in SLC23A1 and SLC23A2 and gastric cancer risk, EPIC-Eurgast study

Gene, SNP	Cases	Controls	OR^a	95 % CL
Gene, SNP	n = 365	n = 1,284	OR^a	95 % CL
SLC23A1
rs6596471
AA	195	665	1	Referent
AG	137	519	0.9	0.70, 1.17
GG	31	99	1.09	0.69, 1.71
rs6596473
GG	163	542	1	Referent
GC	158	565	0.78	0.50, 1.24
CC	29	123	0.93	0.72, 1.21
rs11950646
AA	163	539	1	Referent
AG	163	581	0.95	0.73, 1.23
GG	36	145	0.82	0.54, 1.25
rs33972313^b
GG	346	1,212	1	Referent
GA + AA	19	68	0.99	0.58, 1.71
SLC23A2
rs6052937^b
CC	260	926	1	Referent
CA + AA	104	355	1.07	0.81, 1.39
rs3787456^b
GG	342	1,219	1	Referent
GA + AA	22	64	1.27	0.76, 2.11
rs6116569
CC	92	404	1	Referent
CT	196	616	1.38	1.03, 1.83
TT	76	262	1.32	0.93, 1.88
rs17339746^b
CC	291	1,024	1	Referent
CG + GG	72	255	0.95	0.70, 1.28
rs6052961
CC	156	493	1	Referent
CT	162	606	0.83	0.64, 1.07
TT	47	181	0.79	0.54, 1.16
rs17339942^b
CC	308	1,096	1	Referent
CT + TT	50	169	1.09	0.77, 1.55
rs1776963^b
CC	239	860	1	Referent
CT + TT	124	414	1.09	0.84, 1.40
rs1715380
GG	221	788	1	Referent
GC	128	438	1.03	0.80, 1.33
CC	16	58	0.97	0.54, 1.74
rs6133175
AA	156	554	1	Referent
AG	156	578	0.95	0.73, 1.23
GG	53	152	1.28	0.88, 1.86
rs3914810^c
CC	120	404	1	Referent
CT	133	537	0.83	0.62, 1.11
TT	59	150	1.38	0.94, 2.02
rs6139587
AA	116	385	1	Referent
AT	180	654	0.89	0.67, 1.17
TT	65	226	0.97	0.68, 1.38
rs6053005
CC	115	388	1	Referent
CT	177	658	0.88	0.67, 1.17
TT	72	231	0.98	0.69, 1.39
rs2326576
TT	110	407	1	Referent
TC	176	633	1.04	0.79, 1.37
CC	79	243	1.28	0.91, 1.80
rs6053034^b
GG	247	897	1	Referent
GT + TT	118	387	1.14	0.88, 1.48
rs8126456^b
CC	332	1,169	1	Referent
CT + TT	31	110	1.03	0.67, 1.59
rs1279685
GG	204	746	1	Referent
GA	137	458	1.18	0.91, 1.52
AA	24	79	1.31	0.79, 2.16

SNP single-nucleotide polymorphism
^aOdds ratios (OR) adjusted for age at recruitment (5-year categories), sex, country, smoking status, baseline H. pylori infection status, season of blood draw
^bDominant model evaluated when there were fewer than 10 cases or controls with variant genotypes
^cGenotype data missing for 15 % of participants

ISSN: 1865-3499