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Table 2 Association of 16 BMI or obesity-associated variants with anthropometric measures in the Malmö Diet and Cancer Study

From: Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study

Chr

Gene or nearby gene

SNP (1/2)

BMI (kg/m2)

Height (cm)

Weight (kg)

Waist (cm)

Hip (cm)

β ± SE

P

β ± SE

P

β ± SE

P

β ± SE

P

β ± SE

P

16

FTO

rs9939609 (A/T)

0.32 ± 0.04

7.0 × 10−20

0.11 ± 0.06

0.039

0.99 ± 0.11

2.6 × 10−21

0.70 ± 0.09

3.1 × 10−14

0.62 ± 0.08

3.5 × 10−16

18

MC4R

rs17782313 (C/T)

0.13 ± 0.04

0.002

0.18 ± 0.06

0.004

0.53 ± 0.12

2.3 × 10−5

0.30 ± 0.11

0.005

0.29 ± 0.09

0.001

16

SH2B1

rs7498665 (G/A)

0.086 ± 0.04

0.009

0.019 ± 0.005

0.72

0.27 ± 0.11

0.009

0.30 ± 0.09

0.001

0.27 ± 0.08

2.6 × 10−4

4

GNPDA2

rs10938397 (G/A)

0.12 ± 0.03

0.001

−0.026 ± 0.05

0.64

0.29 ± 0.10

0.003

0.28 ± 0.09

0.001

0.22 ± 0.07

0.002

11

MTCH2

rs10838738 (G/A)

0.038 ± 0.03

0.26

−0.14 ± 0.05

0.014

−0.002 ± 0.10

0.95

0.15 ± 0.09

0.11

0.075 ± 0.08

0.32

1

NEGR1

rs2815752 (T/C)

0.15 ± 0.03

1.3 × 10−5

−0.27 ± 0.05

2.3 × 10−7

0.17 ± 0.10

0.091

0.30 ± 0.09

0.001

0.25 ± 0.07

4.6 × 10−4

3

SFRS10

rs7647305 (C/T)

0.11 ± 0.04

0.005

0.040 ± 0.07

0.55

0.37 ± 0.13

0.004

0.38 ± 0.11

0.001

0.21 ± 0.09

0.022

12

BCDIN3D/FAIM2

rs7138803 (A/G)

0.085 ± 0.03

0.017

0.16 ± 0.05

0.002

0.38 ± 0.10

2.8 × 10−4

0.26 ± 0.09

0.005

0.25 ± 0.07

0.001

1

SEC16B/RASAL2

rs10913469 (C/T)

0.18 ± 0.03

2.9 × 10−5

0.19 ± 0.06

0.003

0.66 ± 0.12

1.2 × 10−7

0.38 ± 0.11

0.001

0.36 ± 0.09

9.8 × 10−5

11

BDNF

rs4923461 (A/G)

0.14 ± 0.04

0.001

0.012 ± 0.07

0.84

0.40 ± 0.13

0.001

0.29 ± 0.11

0.008

0.25 ± 0.09

0.007

19

KCTD15/CHST8

rs29941 (C/T)

0.065 ± 0.04

0.063

−0.053 ± 0.05

0.35

0.14 ± 0.11

0.19

0.081 ± 0.09

0.40

0.084 ± 0.08

0.27

2

TMEM18

rs6548238 (C/T)

0.19 ± 0.04

1.8 × 10−5

0.021 ± 0.07

0.69

0.59 ± 0.13

2.9 × 10−5

0.53 ± 0.12

9.0 × 10−6

0.34 ± 0.10

0.001

6

NCR3/AIF1/BAT2

rs2844479 (T/G)

−0.039 ± 0.04

0.25

0.40 ± 0.05

1.1 × 10−13

0.26 ± 0.10

0.019

−0.037 ± 0.09

0.55

0.10 ± 0.08

0.20

10

PTER locus

rs10508503 (C/T)

−0.004 ± 0.06

0.95

−0.095 ± 0.09

0.36

−0.099 ± 0.10

0.72

0.038 ± 0.15

0.74

−0.036 ± 0.13

0.82

16

MAF locus

rs1424233 (A/G)

0.023 ± 0.03

0.34

−0.18 ± 0.05

4.8 × 10−4

−0.099 ± 0.10

0.48

0.028 ± 0.09

0.62

0.055 ± 0.07

0.34

18

NPC1

rs1805081 (A/G)

0.097 ± 0.03

0.002

0.003 ± 0.05

0.97

0.28 ± 0.10

0.004

0.23 ± 0.09

0.008

0.21 ± 0.07

0.002

  1. All anthropometrics (logarithmically transformed variables) are adjusted for age and sex
  2. Chr chromosome number, SNP single-nucleotide polymorphism, (1/2) 1 refers to the risk allele, 2 refers to other allele; BMI, body mass index
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Genes & Nutrition

ISSN: 1865-3499

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