Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study

Table 4 Association of 16 BMI or obesity-associated variants with measures of body composition among participants of Malmö Diet and Cancer Study

Gene or nearby gene	SNP (1/2)	Body fat (%)		Fat mass (kg)		Fat-free mass (kg)
Gene or nearby gene	SNP (1/2)	β ± SE	P	β ± SE	P	β ± SE	P
FTO	rs9939609 (A/T)	0.24 ± 0.04	4.3 × 10⁻⁸	0.47 ± 0.06	5.6 × 10⁻¹⁶	0.52 ± 0.06	1.8 × 10⁻¹⁸
MC4R	rs17782313 (C/T)	0.071 ± 0.05	0.076	0.19 ± 0.07	0.002	0.33 ± 0.07	3.5 × 10⁻⁶
SH2B1	rs7498665 (G/A)	0.14 ± 0.04	0.005	0.20 ± 0.06	0.001	0.098 ± 0.06	0.077
GNPDA2	rs10938397 (G/A)	0.11 ± 0.04	0.031	0.16 ± 0.06	0.005	0.13 ± 0.06	0.024
MTCH2	rs10838738 (G/A)	0.11 ± 0.04	0.006	0.094 ± 0.06	0.090	−0.087 ± 0.06	0.17
NEGR1	rs2815752 (T/C)	0.17 ± 0.04	3.7 × 10⁻⁵	0.18 ± 0.06	0.001	0.007 ± 0.06	0.88
SFRS10	rs7647305 (C/T)	0.12 ± 0.05	0.028	0.18 ± 0.07	0.006	0.19 ± 0.07	0.013
BCDIN3D/FAIM2	rs7138803 (A/G)	0.068 ± 0.04	0.18	0.17 ± 0.06	0.006	0.21 ± 0.06	2.2 × 10⁻⁴
SEC16B/RASAL2	rs10913469 (C/T)	0.076 ± 0.05	0.21	0.25 ± 0.07	0.001	0.43 ± 0.07	8.8 × 10⁻¹⁰
BDNF	rs4923461 (A/G)	0.065 ± 0.05	0.30	0.15 ± 0.07	0.021	0.25 ± 0.07	0.001
KCTD15/CHST8	rs29941 (C/T)	0.047 ± 0.04	0.37	0.076 ± 0.06	0.21	0.069 ± 0.06	0.24
TMEM18	rs6548238 (C/T)	0.11 ± 0.06	0.037	0.24 ± 0.07	0.001	0.33 ± 0.08	1.9 × 10⁻⁵
NCR3/AIF1/BAT2	rs2844479 (T/G)	−0.12 ± 0.04	0.003	−0.025 ± 0.06	0.56	0.29 ± 0.06	5.0 × 10⁻⁶
PTER locus	rs10508503 (C/T)	0.049 ± 0.07	0.35	0.016 ± 0.10	0.58	−0.10 ± 0.10	0.47
MAF locus	rs1424233 (A/G)	0.063 ± 0.04	0.21	0.006 ± 0.06	0.67	−0.11 ± 0.06	0.072
NPC1	rs1805081 (A/G)	0.091 ± 0.04	0.034	0.14 ± 0.06	0.005	0.14 ± 0.06	0.017

Adjusted for age and sex
BMI body mass index, SNP single-nucleotide polymorphism, (1/2) 1 refers to risk allele, and 2 refers to other allele

ISSN: 1865-3499