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Table 4 Calculated odds ratios (95 % confidence interval) for rs4816 A > G genotypes in NTD versus control cases, classified by NTD subtype and by maternal plasma folate and Hcy levels

From: PCMT1 gene polymorphisms, maternal folate metabolism, and neural tube defects: a case–control study in a population with relatively low folate intake

 

All NTDs

Spina bifida

Anencephaly

n

OR (95 % CI)

n

OR (95 % CI)

n

OR (95 % CI)

Folate low (<25th)ac

 rs4816 AG/GG

5

2.3 (0.56–9.04)

2

1.8 (0.26–12.41)

3

4.1 (0.59–27.92)

 rs4816 AA

6

Referent

3

Referent

2

Referent

Folate high (≥25th)ac

 rs4816 AG/GG

10

2.3 (0.74–6.82)

2

1.1 (0.18–6.49)

6

2.3 (0.63–8.58)

 rs4816 AA

12

Referent

5

Referent

7

Referent

Hcy low (≤75th)bd

 rs4816 AG/GG

13

2.0 (0.74–5.44)

6

1.8 (0.52–6.60)

5

1.5 (0.41–5.78)

 rs4816 AA

14

Referent

7

Referent

7

Referent

Hcy high (>75th)bd

 rs4816 AG/GG

6

2.6 (0.67–10.04)

0

–

6

6.46 (1.15–36.46)

 rs4816 AA

5

Referent

2

Referent

2

Referent

  1. aControl group: 1 (2.7 %) homozygous (GG), 9 (24.3 %) heterozygous AG, and 27 (73.0 %) wild-type homozygous (AA) for the rs4816 A > G polymorphism
  2. bControl group: 1 (2.4 %) homozygous (GG), 12 (29.3 %) heterozygous AG, and 28 (68.3 %) wild-type homozygous (AA) for the rs4816 A > G polymorphism
  3. cDefined 25th percentile of maternal plasma folate levels in all NTDs and control groups as a cut-off value
  4. dDefined 75th percentile of maternal plasma homocysteine (Hcy) levels in all NTDs and control groups as a cut-off value
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Genes & Nutrition

ISSN: 1865-3499

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