Table 1 Up-regulated genes by hgm-FNDF-LC50 and SCFA-LC50 treatments compared with untreated HT-29 cells
Symbol | GenBank | Biological function | Fold regulation | |
|---|---|---|---|---|
hgm-FNDF-LC50 | SCFA-LC50 | |||
Apoptosis | ||||
APAF1 | NM_001160 | Induction of apoptosis | 108.38 | 3.24 |
BID | NM_001196 | Induction of apoptosis | 32.00 | 19.12 |
CASP2 | NM_032982 | Induction of apoptosis | 1.07 | 3.47 |
CASP9 | NM_001229 | Induction of apoptosis | 12.73 | 3.88 |
EI24 | NM_004879 | Induction of apoptosis | 8.57 | – |
FASLG | NM_000639 | Induction of apoptosis | 2.13 | 4.55 |
TNF | NM_000594 | Induction of apoptosis, cell proliferation, inflammatory response | 3.63 | – |
TNFRSF10B | NM_003842 | Induction of apoptosis | 8.46 | 3.11 |
GML | NM_002066 | Induction of apoptosis | 2.27 | 1.64 |
Regulation of cell cycle | ||||
ATR | NM_001184 | Negative regulation of cell cycle, DNA repair | 4.63 | 3.15 |
BAI1 | NM_001702 | Inhibition of angiogenesis and growth | – | 6.90 |
CCNE2 | NM_057749 | Cell cycle checkpoint | 7.94 | – |
CCNG2 | NM_004354 | Cell cycle checkpoint | 3.86 | 5.30 |
CHEK2 | NM_007194 | Cell cycle checkpoint | 1.64 | 3.52 |
E2F3 | NM_001949 | Regulation of cell cycle | – | 3.20 |
GADD45A | NM_001924 | Cell cycle arrest, DNA repair | 1.18 | 1.42 |
NF1 | NM_000267 | Negative regulation of cell cycle | 4.66 | – |
PCBP4 | NM_020418 | Negative regulation of cell cycle, induction of apoptosis | – | 2.23 |
RB1 | NM_000321 | Cell cycle checkpoint | 3.36 | 2.26 |
RPRM | NM_019845 | Negative regulation of cell cycle | 3.58 | 7.00 |
SESN1 | NM_014454 | Negative regulation of cell cycle | 12.38 | 28.18 |
SIRT1 | NM_012238 | Induction of apoptosis, negative regulation of cell cycle | 29.86 | 14.19 |
TSC1 | NM_000368 | Negative regulation of the cell cycle | 1.78 | 10.32 |
Cell proliferation | ||||
IL6 | NM_000600 | Induction of inflammatory response and cell proliferation | 2.14 | 2.69 |
KRAS | NM_004985 | Cell proliferation | 2.81 | 3.96 |
MDM4 | NM_002393 | Negative regulation of cell proliferation | 6.06 | 3.55 |
KAT2B | NM_003884 | Inhibition of cell growth | 3.12 | 12.79 |
PPM1D | NM_003620 | Cell growth and anti-apoptosis | 4.44 | – |
PRKCA | NM_002737 | Cell proliferation | 6.36 | 4.65 |
TNFRSF10D | NM_003840 | Anti-apoptosis, cell survival | 1.82 | 4.49 |
DNA repair | ||||
MLH1 | NM_000249 | DNA repair genes | 2.06 | 3.31 |
MSH2 | NM_000251 | DNA repair genes | 2.57 | 2.31 |