Skip to main content

Table 1 Twenty evolutionarily conserved gene (a) up- and (b) down-regulated in response to dietary restriction

From: Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans

 

Symbola

IDb

CLc

FCd

Functione

Hf

Lg

Ih

(a)

droe-8

ZC196.6

UNK

6,3

Growth

61

0

–

droe-1

F21F3.3

AA

27,2

Amino acid methylation

73

1

–

droe-5

T09B9.2

TRA

3,6

Transporter protein

88

0

1

tsp-15

F53B6.1

FO

1,5

Tetraspanin family

86

6

0

ftn-1

C54F6.14

GA

56

Ferritin heavy chain homologs

99

17

0.08

fkb-4

ZC455.10

FO

3,3

Regulated by DAF-2

85

6

1

–

C05D11.7

FO

1,6

Lipid metabolic process

33

2

0

sup-12

T22B2.4a

FO

2,1

Cytoskeleton

85

11

0.72

cpr-2

F36D3.9

AA

200

Cysteine protease related

97

3

0.04

mtl-1

 

MET

146

Metallothionein

68

47

0.05

–

C33A11.1

FO

2,1

Protein binding

31

0

0

hsp-12.6

F38E11.2

HSP

31,7

Heat shock protein

72

14

0.72

nhr-85

W05B5.3a

FO

1,8

Dauer formation

59

9

0.1

ikb-1

C04F12.3

FO

5,9

Immune response

36

11

0

prk-1

C06E8.3a

FO

1,9

 

46

9

0.05

ins-35

K02E2.4

SMS

10,0

Insulin-related peptide

35

1

0

odr-10

C53B7.5

AND

5,7

G-protein-coupled receptor

20

85

0.05

droe-4

F58E10.7

AND

5,2

Amyloid beta protein binding

30

0

0.63

nlp-35

C33A12.2

SMS

8,2

Neuropeptide-like protein

23

3

0

ugt-36

F09G2.6

LIP

2,4

UDP-glucuronosyl transferase

95

0

0

(b)

drd-1

F49E12.9

MIT

4,9

Sterol desaturase

99

0

0.67

gba-4

Y4C6B.6

LYS

5,5

Beta-glucocerebrosidase

99

0

–

vit-1

K09F5.2

LIP

49,5

Vitellogenin protein

67

17

0.38

drd-3

W07B8.1

AA

6,8

Cysteine proteinase

98

0

0.1

drd-50

F49F1.1

LYS

16,3

Secreted surface protein

66

2

–

folt-2

F37B4.7

TRA

23,8

Folate transporter family

96

1

0.33

swt-6

R10D12.9

LIP

7,9

Sugar efflux transporter

68

0

0

msi3p

C30C11.4

HSP

1,8

Heat shock protein

99

5

–

drd-51

C48B4.1

LIP

5,3

Nhr-49 ard starv sensing

98

2

0.1

drd-2

F40F4.6

MAP

16,7

Wnt inhibitory factor 1

7

0

0.06

drd-4

F57F5.1

AA

11,1

Cathepsin

89

0

0.4

hmit-1.1

Y51A2D.4

TRA

1,5

H(+) Myoinositol transporters

90

1

0.04

drd-100

F08A8.2

LIP

2,8

Acyl coenzyme A oxidase

98

5

0.29

dhs-7

E04F6.7

MIT

3,3

Dehydrogenases

97

1

0.87

drd-5

F55E10.6

MIT

4,3

Dihydroxybenzoate dehydrogenase

92

0

0

drd-6

F13H8.3

NAD

7,7

Nucleoside hydrolase,

56 (fly)

0

1

pcp-3

F23B2.11

LYS

3,8

Serine protease

41

1

0.2

pcp-2

F23B2.12

LYS

18,3

Lysosomal serine-type peptidase

35

1

–

drd-7

K10B2.2

LYS

6,7

Intrinsic/integral to membrane

98

0

0

drd-8

Y40D12A.2

LYS

5,9

Lysosomal protective protein

93

0

0.17

col-135

M199.5

COL

1,7

Collagen alpha-1

91

0

–

drd-9

F18E2.1

MET

3

Purple acid phosphatase

91

0

0

nep-17

F54F11.2

MET

6

Neprilysin, metallopeptidases

48

2

0

drd-10

C33G8.3

AND

6,7

Mannosylphosphate transferase

85

0

0

mup-4

K07D8.1

AND

4

Muscle positioning

53

24

0.9

  1. All assigned genes have been similarly regulated under DR in at least five out of seven approaches
  2. Genes showing up in more than one class have been annotated to the most obvious category
  3. IMU innate immunity, CLD, FO functional ortholog of mouse genes, AA amino acid metabolism, LIP lipid homeostasis, AND other functions, SMS small signaling molecules, HSP HIS heat shock proteins or histones, TRA transport processes MIT mitochondrial function, NAD NADH, MAP MAPK, SKP skp-1, LYS lysis, SEC secreted proteins, COL collagens, MET metallothionein metabolism
  4. a Gene name
  5. b Gene ID
  6. c Functional classification
  7. d Maximal fold change DR/AL in microarray assays
  8. e Most prominent (predicted) function
  9. f % Homology to the closest human ortholog
  10. g Appearance in literature, without
  11. h Interactors in this study/total interactors
Back to article page

Genes & Nutrition

ISSN: 1865-3499

Contact us