Fig. 4

Comparison of mRNA expression levels of some lipid metabolism-related genes in PBMCs with the expression determined in inguinal and retroperitoneal WAT and liver of male and female offspring of control and at 6 months of age. Only those genes with significant differences between control and CR animals in PBMCs of adult animals are shown. mRNA levels were measured by RT-qPCR and expressed as a percentage of the mean value of males control. Data are mean ± SEM (n = 6–8 animals/group). Statistics: R, effect of maternal calorie restriction during lactation; RxS, an interaction between the effect of maternal calorie restriction during lactation and the effect of sex (p < 0.05; two-way ANOVA). *, CR vs Controls (p < 0.05; Student’s t test); Corr, consistent positive correlations between mRNA expression levels of selected genes involved in lipid metabolism in PBMCs and mRNA expression levels of those genes in iWAT, rWAT and liver of male and female offspring of control and calorie-restricted dams during lactation (CR) at the age of 6 months; r, Pearson’s correlation coefficient; p-value of the genetic correlation (p < 0.05); – indicates no correlations