Table 1 Polymorphisms potentially affecting zinc homeostasis
From: Zinc and the aging brain
Gene | Putative role in zinc homeostasis | Polymorphism | Disease risk |
|---|---|---|---|
MT1A | Buffering and chaperone | +647A/C | DM2 |
MT2A | Buffering and chaperone | −209A/G | DM2 |
SLC30A8 | Sequestration in secretory vesicles | R325Â W | DM1&2 |
IL6 | Regulates MT and A2 M | −174G/C | AD |
A2M | Extracellular transport | −88A/G and 25T/G | AD |
APOE | Unknown | C112R | AD |