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Table 1 Polymorphisms potentially affecting zinc homeostasis

From: Zinc and the aging brain

Gene Putative role in zinc homeostasis Polymorphism Disease risk
MT1A Buffering and chaperone +647A/C DM2
MT2A Buffering and chaperone −209A/G DM2
SLC30A8 Sequestration in secretory vesicles R325 W DM1&2
IL6 Regulates MT and A2 M −174G/C AD
A2M Extracellular transport −88A/G and 25T/G AD
APOE Unknown C112R AD