Table 4 Adjusted aORs and 95 % CI for the effect of the interaction of candidate genes with lifestyle factors on the development of NAFLD (234 cases and 349 controls)
Alcohol intake | Fruit intake | Grilled meat or fish intake | ||||
|---|---|---|---|---|---|---|
Never drinkers | Males: <30 g Females: <20 g | 0–2/day | >2/day | 0–1/week | >1/week | |
GSTM1 | ||||||
Present | 1.00 | 0.56 [0.29; 1.07] | 1.00 | 3.06 [1.60; 5.84] | 1.00 | 1.83 [0.96; 3.46] |
Null | 0.89 [0.48; 1.66] | 0.56 [0.29; 1.07] p b = 0.081 | 0.77 [0.41; 1.45] | 3.55 [1.88; 6.68] p < 0.001 | 0.68 [0.34; 1.36] | 2.18 [1.18; 4.03] p = 0.013 |
GSTT1 | ||||||
Present | 1.00 | 0.59 [0.35; 1.01] | 1.00 | 4.23 [2.46; 7.29] | 1.00 | 2.65 [1.54; 4.58] |
Null | 1.47 [0.71; 3.06] | 0.85 [0.41; 1.76] p = 0.655 | 1.83 [0.89; 3.76] [−0.829; 0.732] | 4.82 [2.26;10.32] p < 0.001 | 1.82 [0.82; 4.03] [−0.856;0.726] | 3.26 [1.57; 6.79] p = 0.002 |
CYP1A1 | ||||||
CYP1A1*1/*1 | 1.00 | 0.55 [0.32; 0.94] | 1.00 | 3.06 [1.80; 5.20] | 1.00 | 2.37 [1.39; 4.04] |
CYP1A1*2A carriers | 0.92 [0.43; 1.99] | 0.70 [0.34; 1.43] p = 0.326 | 0.72 [0.34; 1.53] | 5.17 [2.37;11.27] p < 0.001 | 1.10 [0.48; 2.51] [−0.686; 0.779] | 2.59 [1.25; 5.36] p = 0.011 |
CYP2E1 PstI | ||||||
CYP2E1*1A/1A | 1.00 | 0.62 [0.38; 1.00] | 1.00 | 3.82 [2.34; 6.25] | 1.00 | 2.23 [1.37; 3.62] |
CYP2E1*5B carriers | 0.92 [0.28; 3.08] | 0.25 [0.06; 0.98] p = 0.046 | 0.68 [0.18; 2.58] | 2.31 [0.71; 7.47] p = 0.163 | 0.41 [0.10; 1.71] | 1.93 [0.59; 6.28] p = 0.273 |
CYP2E1 DraI | ||||||
CYP2E1*1A/1A | 1.00 | 0.56 [0.34; 0.92] | 1.00 | 3.53 [2.14; 5.82] | 1.00 | 2.38 [1.45; 3.91] |
CYP2E1*6 carriers | 1.09 [0.36; 3.32] | 0.92 [0.22; 3.80] p = 0.911 | 0.52 [0.13; 2.05] | 11.34 [2.70;47.55] p = 0.001 | 2.32 [0.37; 14.67] [−2.547; 1.682] | 2.58 [0.95; 7.04] p = 0.063 |
SULT1A1 | ||||||
SULT1A1*1/*1 | 1.00 | 0.55 [0.30; 1.01] | 1.00 | 4.05 [2.17; 7.53] | 1.00 | 2.07 [1.12; 3.83] |
SULT1A1*2carriers | 1.04 [0.56; 1.94] | 0.71 [0.36; 1.38] p = 0.314 | 1.28 [0.68; 2.42] [−0.697; 0.624] | 4.18 [2.20; 7.94] p < 0.001 | 0.97 [0.48; 1.95] | 2.69 [1.42; 5.10] p = 0.002 |