Variation in genes related to hepatic lipid metabolism and changes in waist circumference and body weight

Meidtner, Karina; Fisher, Eva; Ängquist, Lars; Holst, Claus; Vimaleswaran, Karani S.; Boer, Jolanda M. A.; Halkjær, Jytte; Masala, Giovanna; Østergaard, Jane N.; Mortensen, Lotte M.; van der A, Daphne L.; Tjønneland, Anne; Palli, Domenico; Overvad, Kim; Wareham, Nicholas J.; Loos, Ruth J. F.; Sørensen, Thorkild I. A.; Boeing, Heiner

doi:10.1007/s12263-014-0385-7

Genes & Nutrition

Table 2 Nominally significant SNP main effect, SNP x diet interaction, and SNP x sex interaction of genetic variants in selected candidate genes for baseline BMI, and annual changes in waist circumference and body weight

From: Variation in genes related to hepatic lipid metabolism and changes in waist circumference and body weight

Gene	SNP	SNP type^d	Outcome	Estimate^c	β (SE)^a,b	p value^a
ATF6	rs10918092	Intron	Waist change	SNP × carb	0.03 (0.02)	0.03
ATF6	rs12130299	Upstream	Weight change	SNP × mufa	−60.7 (25.7)	0.02
			Weight change	SNP × sfa	−55.8 (25.0)	0.03
			Weight change	SNP × fat	−27.1 (12.2)	0.03
ATF6	rs2499854	3′ UTR	Waist change	SNP × pufa	0.13 (0.06)	0.03
ATF6	rs4657101	Intron	Waist change	SNP × sex	0.09 (0.04)	0.03
ATF6	rs4657101	Intron	Waist change	SNP × GI	−0.01 (0.01)	0.04
FABP1	rs2919871	Intron, nc	Waist change	SNP × sex	−0.08 (0.04)	0.04
			Weight change	SNP × sfa	81.4 (24.9)	0.001
			Weight change	SNP × fat	25.1 (12.3)	0.04
FABP1	rs2970902	Upstream	Weight change	SNP × sfa	69.1 (26.4)	0.009
FABP1	rs2970902	Upstream	Weight change	SNP × fat	29.8 (11.5)	0.01
FABP1	rs2970903	Upstream	Weight change	SNP × GI	−11.1 (5.5)	0.04
FABP1	rs894194	Downstream	Baseline BMI	SNP	−0.16 (0.07)	0.03
LPIN2	rs10438875	Upstream	Baseline BMI	SNP	0.17 (0.09)	0.05
LPIN2	rs1164	3′ UTR	Weight change	SNP × sex	−111.5 (30.9)	0.0003
LPIN2	rs11661932	Intron	Weight change	SNP × carb	−47.3 (22.5)	0.04
LPIN2	rs11665524	Intron	Waist change	SNP × pufa	−0.15 (0.08)	0.05
LPIN2	rs3934427	Intron, nc	Waist change	SNP × carb	0.05 (0.02)	0.01
			Waist change	SNP × fat	−0.07 (0.04)	0.05
			Weight change	SNP × carb	44.1 (14.3)	0.002
LPIN2	rs4797092	Intron	Weight change	SNP × GI	17.0 (7.2)	0.02
LPIN2	rs6506041	Upstream	Weight change	SNP × carb	−24.4 (10.0)	0.01
LPIN2	rs6506041	Upstream	Weight change	SNP × mufa	50.4 (25.4)	0.05
LPIN3	rs12625565	Missense (Q679H)	Waist change	SNP × sfa	0.09 (0.04)	0.02
LPIN3	rs16985665	Upstream	Weight change	SNP × pufa	102.7 (47.1)	0.03
LPIN3	rs4810312	Upstream	Waist change	SNP × mufa	0.07 (0.03)	0.04
			Weight change	SNP × mufa	65.5 (28.0)	0.02
			Weight change	SNP × fat	33.4 (15.0)	0.03
			Weight change	SNP × carb	−20.7 (9.4)	0.03
LPIN3	rs6029636	Upstream	Weight change	SNP × mufa	56.1 (26.4)	0.03
MLXIPL	rs11760752	Intron	Weight change	SNP × sex	65.5 (31.2)	0.04
MLXIPL	rs6967028	Upstream	Weight change	SNP	−50.5 (25.3)	0.05
MTTP	rs1057613	3′ UTR	Weight change	SNP	28.8 (14.4)	0.04
MTTP	rs3816873	Missense (I128T)	Weight change	SNP	38.2 (16.5)	0.02

^aOverall estimate (β), standard error (SE) and p value from meta-analysis
^bFor waist change in cm/year per minor allele, for weight change in g/year per minor allele, for baseline BMI in kg/m² per minor allele
^c carb increment of 5 % energy from carbohydrates, fat increment of 5 % energy from fat, sfa increment of 5 % energy from saturated fatty acids, mufa increment of 5 % energy from monounsaturated fatty acids, pufa increment of 5 % energy from polysaturated fatty acids, GI glycaemic index
^d nc non-coding transcript

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