Table 1 Comparison of genotype and allele frequencies of MTHFR C677T, MTHFR A1298C, SLC19A1 G80A, SLC19A1 C696T, MTRR A66G polymorphisms between REPL patients and control subjects
Genotype and allele | Control (n = 166) | Case (n = 82) | AOR (95 % CI) | P value |
|---|---|---|---|---|
MTHFR C677T | ||||
 CC | 53 (0.319) | 29 (0.354) | 1.0 (ref) | – |
 CT | 83 (0.500) | 43 (0.524) | 0.92 (0.51–1.68) | 0.794 |
 TT | 30 (0.181) | 10 (0.122) | 0.56 (0.23–1.33) | 0.185 |
 CT+TT |  |  | 0.82 (0.47–1.46) | 0.507 |
 C | 189 (0.569) | 101 (0.616) | 1.0 (ref) | – |
 T | 143 (0.431) | 63 (0.384) | 0.79 (0.54–1.17) | 0.246 |
MTHFR A1298C | ||||
 AA | 132 (0.795) | 49 (0.598) | 1.0 (ref) | – |
 AC | 31 (0.187) | 31 (0.378) | 2.58 (1.40–4.74)# | 0.002 |
 CC | 3 (0.018) | 2 (0.024) | 2.00 (0.32–12.47) | 0.459 |
 AC+CC |  |  | 2.53 (1.40–4.57) | 0.002 |
 A | 295 (0.889) | 129 (0.787) | 1.0 (ref) | – |
 C | 37 (0.111) | 35 (0.213) | 2.13 (1.27–3.57) | 0.004 |
SLC19A1 G80A | ||||
 GG | 45 (0.271) | 22 (0.268) | 1.0 (ref) | – |
 GA | 94 (0.566) | 37 (0.451) | 0.86 (0.45–1.64) | 0.643 |
 AA | 27 (0.163) | 23 (0.281) | 1.84 (0.85–3.98) | 0.122 |
 GA+AA |  |  | 1.08 (0.59–1.99) | 0.807 |
 G | 184 (0.554) | 81 (0.494) | 1.0 (ref) | – |
 A | 148 (0.446) | 83 (0.506) | 1.31 (0.89–1.93) | 0.165 |
SLC19A1 C696T | ||||
 CC | 45 (0.271) | 23 (0.280) | 1.0 (ref) | – |
 CT | 94 (0.566) | 35 (0.427) | 0.76 (0.40–1.46) | 0.411 |
 TT | 27 (0.163) | 24 (0.293) | 1.86 (0.87–3.99) | 0.110 |
 CT+TT |  |  | 1.00 (0.55–1.84) | 0.988 |
 C | 184 (0.554) | 81 (0.494) | 1.0 (ref) | – |
 T | 148 (0.446) | 83 (0.506) | 1.32 (0.90–1.93) | 0.158 |
MTRR A66G | ||||
 AA | 98 (0.590) | 43 (0.524) | 1.0 (ref) | – |
 AG | 53 (0.319) | 28 (0.341) | 1.12 (0.62–2.04) | 0.701 |
 GG | 15 (0.090) | 11 (0.134) | 1.69 (0.71–4.06) | 0.239 |
 AG+GG |  |  | 1.25 (0.72–2.15) | 0.429 |
 A | 249 (0.750) | 114 (0.695) | 1.0 (ref) | – |
 G | 83 (0.250) | 50 (0.305) | 1.29 (0.84–1.97) | 0.241 |