Fig. 3
From: Genetic associations with micronutrient levels identified in immune and gastrointestinal networks
Conceptual approach for gene selection. The analysis focused on SNPs within genes with known functional association with the metabolites (orange rectangles) measured in the study. This was accomplished by mining all genes from the MetaCore database with a direct functional connection to any of these metabolites. This resulted in 275 unique genes, designated as micronutrient neighbor genes (black balls). In parallel, a global metabolic/PPI interaction network was partitioned into topological modules. Modules that were significantly enriched in micronutrient neighborhood genes were defined as micronutrient systems