Genetic predisposition scores for dyslipidaemia influence plasma lipid concentrations at baseline, but not the changes after controlled intake of n-3 polyunsaturated fatty acids

Table 3 Effect of GPS on change in plasma TC, HDL-C, LDL-C and TG concentrations after treatment

	Effect	SE	P*	r ²	n
Change in TC (mmol/L)	0.064	0.031	0.30	0.092	251
Change in HDL-C (mmol/L)	0.016	0.011	0.80	0.014	250
Change in LDL-C (mmol/L)	0.054	0.020	0.41	0.011	251
Change in TG (mmol/L)	−0.023	0.011	0.72	0.032	251

Data show associations of GPS with change in each trait, presented as per allele effect size, and SE derived from linear regression models of GPS against change in trait. The proportion of explained variance is indicated by r ², and n is the number of participants in each subgroup. A negative effect represents an association with reduction in trait following 12-month intervention
HDL-C high-density-lipoprotein cholesterol, LDL-C low-density-lipoprotein cholesterol, TC total cholesterol, TG triglyceride
* Significance of per allele effect on change in trait derived from linear regression models, nominal at P < 0.05. P values adjusted for trait value at baseline, BMI, age, gender and ethnicity

ISSN: 1865-3499