Strong influence of dietary intake and physical activity on body fatness in elderly Japanese men: age-associated loss of polygenic resistance against obesity

Table 1 SNPs selected to calculate GRS

SNP	Gene symbol	Chromosome	Base pair position (GRCh37.p10)	Allele (M/m)	Risk allele	MAF	β*	HWE p
rs543874	SEC16B	1	177889480	A/G	G	0.22	6.57	0.662
rs2867125	TMEM18	2	622827	C/T	C	0.08	5.05	0.614
rs713586	ADCY3	2	25158008	T/C	C	0.46	2.94	0.457
rs10938397	GNPDA2	4	45182527	A/G	G	0.33	3.71	0.091
rs987237	TFAP2B	6	50803050	A/G	G	0.25	3.84	0.847
rs6265	BDNF	11	27679916	T/C	C	0.40	4.53	0.537
rs2241423	MAP2K5	15	68086838	A/G	G	0.33	3.10	1.000
rs17817449	FTO	16	53813367	T/G	G	0.19	8.46	0.144
rs10871777	MC4R	18	57851763	A/G	G	0.24	5.64	0.223
rs3810291	TMEM160	19	47569003	A/G	A	0.23	3.48	0.003

GRS genetic risk score, HWE Hardy–Weinberg equilibrium, M major allele, m minor allele, MAF minor allele frequency, SNP single nucleotide polymorphism
* Effect of SNPs per allele on BMI (in percentage of the SD) derived from the meta-analysis (Wen et al. 2012)

ISSN: 1865-3499