Table 2 Genotype, minor allele frequency (MAF) and Hardy–Weinberg equilibrium calculations of the 16 SNPs included in the GRS
Gene | SNP | Major/minor allelea | Major allele homozygote (%) | Heterozygote (%) | Minor allele homozygote (%) | MAF | HWE p value |
|---|---|---|---|---|---|---|---|
FTO | rs9939609 | T/A | 218 (30.6) | 351 (49.4) | 142 (20.0) | 0.45 | 0.973 |
MC4R | rs17782313 | T/C | 442 (62.2) | 237 (33.3) | 32 (4.5) | 0.21 | 0.974 |
MTHFR | rs1801133 | C/T | 257 (36.2) | 340 (47.8) | 114 (16.0) | 0.40 | 0.930 |
PPARA | rs1800206 | C/G | 591 (83.1) | 116 (16.3) | 3 (0.5) | 0.09 | 0.507 |
PPARG | rs1801282 | C/G | 594 (82.5) | 110 (15.5) | 7 (1.0) | 0.09 | 0.453 |
APOA5 | rs662799 | T/C | 620 (87.2) | 88 (12.4) | 3 (0.4) | 0.07 | 0.948 |
APOE | rs429358 | T/C | 574 (80.7) | 129 (18.1) | 8 (1.1) | 0.10 | 0.804 |
APOE | rs7412 | C/T | 624 (87.8) | 84 (11.8) | 3 (0.4) | 0.06 | 0.923 |
LIPC | rs1800588 | C/T | 406 (57.1) | 250 (36.3) | 47 (6.6) | 0.24 | 0.489 |
PLIN1 | rs894160 | G/A | 378 (53.2) | 282 (39.7) | 51 (7.2) | 0.27 | 0.872 |
NOS3 | rs1799983 | G/T | 286 (40.2) | 326 (45.8) | 99 (13.9) | 0.37 | 0.692 |
GCKR | rs1260326 | C/T | 208 (29.2) | 367 (50.9) | 141 (19.8) | 0.45 | 0.465 |
LPL | rs328 | C/G | 510 (71.7) | 189 (26.6) | 12 (1.7) | 0.15 | 0.244 |
CELSR2 | rs12740374 | G/T | 440 (61.9) | 241 (33.9) | 30 (4.2) | 0.21 | 0.676 |
CETP | rs1800777 | G/A | 681 (95.8) | 28 (3.9) | 2 (0.3) | 0.02 | 0.005 |
LIPG | rs4939883 | C/T | 508 (71.4) | 179 (25.2) | 24 (3.4) | 0.16 | 0.100 |