A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intake

Table 3 Linear regression coefficients and logistic regression coefficients for the association between GRS (dichotomized by the median) and several anthropometric variables

	Linear regression coefficients				Logistic regression coefficients
	Model 1		Model 2		Model 1		Model 2
	B (95 % CI)	p value	B (95 % CI)	p value	OR (95 % CI)	p value	OR (95 % CI)	p value
BMI (kg/m²)
≤7 risk alleles	0 (ref.)		0 (ref.)		1 (ref.)		1 (ref.)
>7 risk alleles	1.02 (0.17–1.87)	0.019	0.93 (0.17–1.68)	0.016	1.41 (1.04–1.93)	0.031	1.42 (1.02–1.99)	0.038
Percentage of BFM
≤7 risk alleles	0 (ref.)		0 (ref.)		1 (ref.)		1 (ref.)
>7 risk alleles	1.81 (0.59–3.03)	0.004	1.69 (0.58–2.80)	0.003	1.72 (1.22–2.42)	0.002	1.72 (1.19–2.48)	0.004
Waist circumference (cm)
≤7 risk alleles	0 (ref.)		0 (ref.)		1 (ref.)		1 (ref.)
>7 risk alleles	2.14 (0.08–4.21)	0.042	1.94 (0.12–3.75)	0.036	1.54 (1.04–2.29)	0.032	1.57 (1.02–2.40)	0.039
Waist-to-hip ratio
≤7 risk alleles	0 (ref.)		0 (ref.)		1 (ref.)		1 (ref.)
>7 risk alleles	0.00 (−0.01–0.002)	0.445	0.00 (−0.01–0.01)	0.480	1.15 (0.82–1.61)	0.401	1.14 (0.81–1.61)	0.454
Waist-to-height ratio
≤7 risk alleles	0 (ref.)		0 (ref.)		1 (ref.)		1 (ref.)
>7 risk alleles	0.01 (0.00–0.03)	0.036	0.01 (0.00–0.02)	0.029	1.39 (0.95–2.02)	0.089	1.41 (0.94–2.10)	0.096

Model 1: Adjusted for gender and age
Model 2: Adjusted for gender, age, physical activity and energy intake
BMI body mass index, BMF body fat mass, 95 % CI 95 % confidence interval, OR odds ratio

ISSN: 1865-3499