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Table 4 The dietary intake modifies the GRS association with BFM (%) and the obesity risk (as % of BFM)

From: A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intake

 

β (SE)

p value

p value for interaction

OR (95 % CI)

p value

p value for interaction

Energy intake (kcal)

 ≤7 risk alleles

0.17 (0.05)

<0.001

 

1.00 (1.00–1.00)

0.041

 

 >7 risk alleles

0.39 (0.04)

<0.001

0.002*

1.00 (1.00–1.00)

<0.001

<0.001*

Total protein (g)

 ≤7 risk alleles

0.11 (0.06)

0.060

 

1.01 (0.99–1.02)

0.302

 

 >7 risk alleles

0.20 (0.04)

<0.001

0.003*

1.02 (1.00–1.03)

0.037

0.001*

Animal protein (g)

 ≤7 risk alleles

0.09 (0.05)

0.053

 

1.01 (0.99–1.02)

0.261

 

 >7 risk alleles

0.13 (0.04)

0.002

0.032

1.01 (1.00–1.03)

0.080

0.021*

Vegetable protein (g)

 ≤7 risk alleles

−0.06 (0.06)

0.340

 

0.98 (0.94–1.03)

0.484

 

 >7 risk alleles

0.02 (0.06)

0.730

0.003*

1.01 (0.96–1.06)

0.657

0.001*

Total fat (g)

 ≤7 risk alleles

0.05 (0.05)

0.349

 

1.01 (0.99–1.02)

0.326

 

 >7 risk alleles

0.07 (0.05)

0.179

0.029

1.01 (0.99–1.02)

0.324

0.017*

SFA (g)

 ≤7 risk alleles

−0.00 (0.06)

0.938

 

1.00 (0.93–1.07)

0.945

 

 >7 risk alleles

0.03 (0.05)

0.537

0.015*

0.99 (0.93–1.05)

0.810

0.017*

MUFA (g)

 ≤7 risk alleles

0.07 (0.05)

0.139

 

1.02 (0.99–1.05)

0.144

 

 >7 risk alleles

0.07 (0.04)

0.123

0.121

1.02 (0.99–1.04)

0.177

0.082

PUFA (g)

 ≤7 risk alleles

−0.05 (0.06)

0.388

 

0.96 (0.87–1.05)

0.365

 

 >7 risk alleles

0.04 (0.05)

0.396

0.002*

1.06 (0.95–1.18)

0.279

0.004*

Diet cholesterol (mg)

 ≤7 risk alleles

0.09 (0.05)

0.061

 

1.00 (1.00–1.00)

0.492

 

 >7 risk alleles

0.06 (0.04)

0.163

0.309

1.00 (1.00–1.00)

0.492

0.090

Total carbohydrates (g)

 ≤7 risk alleles

−0.03 (0.05)

0.638

 

1.00 (0.99–1.00)

0.461

 

 >7 risk alleles

0.05 (0.05)

0.318

0.008*

1.00 (1.00–1.01)

0.402

0.001*

Simple carbohydrates (g)

 ≤7 risk alleles

−0.17 (0.05)

<0.001

 

0.99 (0.98–1.00)

0.005

 

 >7 risk alleles

−0.16 (0.04)

<0.001

0.270

0.97 (0.96–0.98)

<0.001

0.997

Complex carbohydrates (g)

 ≤7 risk alleles

0.05 (0.05)

0.387

 

1.00 (0.99–1.01)

0.559

 

 >7 risk alleles

0.08 (0.05)

0.153

0.030

1.01 (1.00–1.01)

0.049

0.001*

Fiber (g)

 ≤7 risk alleles

−0.09 (0.05)

0.101

 

0.97 (0.93–1.01)

0.188

 

 >7 risk alleles

−0.06 (0.05)

0.245

0.039

0.96 (0.92–1.00)

0.048

0.059

  1. Adjusted for gender, age, physical activity and energy intake
  2. SFA saturated fatty acids, MUFA monounsaturated fatty acids, PUFA polyunsaturated fatty acids, SE standard error, 95 % CI 95 % confidence interval
  3. * p value <0.05 Benjamini–Hochberg correction for multiple comparisons
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Genes & Nutrition

ISSN: 1865-3499

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