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Table 2 Odds Ratios (ORs) for the associations between breast cancer risk, MTHFR and MTR single-nucleotide polymorphisms (SNPs) in the MASTOS study

From: Single-nucleotide polymorphisms in one-carbon metabolism genes, Mediterranean diet and breast cancer risk: a case–control study in the Greek-Cypriot female population

Gene/SNP

Cases/Controlsa

Adjustedb OR (95 % CI)c

P value

MTHFR 677C>T (rs1801133)

C/C

361/436

1.00

–

C/T

516/525

1.16 (0.96–1.40)

0.12

T/T

188/193

1.19 (0.92–1.52)

0.18

   

P trend 0.13

MTHFR 1298A>C (rs1801131)

A/A

138/150

1.00

–

A/C

465/500

1.03 (0.79–1.35)

0.83

C/C

468/484

1.06 (0.81–1.39)

0.67

   

P trend 0.97

MTR 2756A>G (rs1805087)

A/A

679/681

1.00

–

A/G

350/404

0.87 (0.73–1.05)

0.14

G/G

45/68

0.69 (0.46–1.02)

0.06

   

P trend 0.12

  1. aThe number of cases and controls may differ from those of Table 1 due to confounder missing values
  2. bAdjusted for menopausal status and age
  3. c95 % CI: 95 % confidence interval
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Genes & Nutrition

ISSN: 1865-3499

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