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Table 3 Interactions between MTHFR, MTR single-nucleotide polymorphisms (SNPs) and principal component analysis (PCA)-derived Mediterranean dietary patterna and their effect on breast cancer risk in the MASTOS study

From: Single-nucleotide polymorphisms in one-carbon metabolism genes, Mediterranean diet and breast cancer risk: a case–control study in the Greek-Cypriot female population

Gene/SNP

PCA-derived Mediterranean dietary pattern intake quartilesb: vegetables, fruit, legumes, fish

Quartile 1

Quartile 2

Quartile 3

Quartile 4

Cases/Controls

Adjustedc OR (95 % CI)

Cases/Controls

Adjustedc OR (95 % CI)

Cases/Controls

Adjustedc OR (95 % CI)

Cases/Controls

Adjustedc OR (95 % CI)

MTHFR 677C>T (rs1801133)

C/C

98/96

1.00

90/103

0.86 (0.57–1.30)

85/106

0.78 (0.52–1.19)

88/129

0.67 (0.45–1.01)

C/T

141/121

1.16 (0.79–1.71)

135/131

0.98 (0.67–1.43)

133/130

0.97 (0.66–1.43)

106/142

0.70 (0.47–1.03)

T/T

58/35

1.77 (1.06–2.98)

55/42

1.30 (0.78–2.15)

39/61

0.59 (0.35–0.97)

35/54

0.66 (0.39–1.12)

P-trendd

0.65

0.60

0.20

0.83

P-interactione 0.15

MTHFR 1298A>C (rs1801131)

        

A/A

34/34

1.00

35/32

1.08 (0.54–2.16)

38/30

1.28 (0.64–2.56)

31/54

0.55 (0.28–1.07)

A/C

131/125

1.08 (0.62–1.87)

121/118

0.99 (0.57–1.72)

110/121

0.91 (0.52–1.58)

103/134

0.77 (0.44–1.34)

C/C

137/92

1.56 (0.89–2.72)

121/117

1.07 (0.62–1.87)

112/140

0.77 (0.44–1.33)

96/133

0.68 (0.39–1.19)

P-trendd

0.36

0.54

0.55

0.19

P-interactione 0.14

MTR 2756A>G (rs1805087)

        

A/A

193/148

1.00

171/155

0.86 (0.63–1.17)

161/181

0.68 (0.50–0.92)

154/194

0.59 (0.43–0.81)

A/G

99/95

0.83 (0.58–1.19)

95/96

0.71 (0.49–1.03)

88/104

0.63 (0.44–0.92)

67/108

0.49 (0.34–0.72)

G/G

11/11

0.98 (0.40–2.43)

11/22

0.38 (0.18–0.83)

11/12

0.62 (0.26–1.47)

11/23

0.37 (0.17–0.79)

P-trendd

0.37

0.27

0.63

0.38

P-interactione 0.87

  1. The P values (<0.05), which are statistically significant, are presented in bold. The odds ratios (ORs) (95 % confidence interval (CI)) which correspond to the statistically significant P values are also presented in bold
  2. a PCA-derived dietary pattern with high loadings of vegetables, fruit, legumes and fish, thus closely resembling the Mediterranean diet
  3. bQuartiles of adherence to PCA-derived Mediterranean dietary pattern, with subjects in quartile 1, showing the lowest consumption of vegetables, fruit, legumes and fish, and thus, lowest adherence to this dietary pattern and with subjects in quartile 4, showing the highest consumption of the same four food groups and therefore highest adherence to this dietary pattern
  4. cAdjusted for menopausal status, age and for the other PCA-derived dietary components (Patterns 1, 2 and 3)
  5. d P for trend within each quartile of adherence to the PCA-derived Mediterranean dietary pattern across the three genotypes of each SNP
  6. e P for interaction between quartiles of adherence to the PCA-derived Mediterranean dietary pattern and genotypes of each SNP, derived from a likelihood ratio test comparing regression models with and without gene-dietary pattern interactions
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Genes & Nutrition

ISSN: 1865-3499

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