Single-nucleotide polymorphisms in one-carbon metabolism genes, Mediterranean diet and breast cancer risk: a case–control study in the Greek-Cypriot female population

Table 4 Associations between breast cancer risk and principal component analysis (PCA)-derived Mediterranean dietary pattern^a, stratified by genotypes of MTHFR and MTR single-nucleotide polymorphisms (SNPs) in the MASTOS study

Gene/SNP	Dietary pattern quartiles^b: vegetables, fruit, legumes, fish	Cases/Controls	Adjusted^c OR (95 % CI)	P-trend^d
MTHFR 677C>T (rs1801133)
C/C	Quartile 1	98/96	1.00	0.04
	Quartile 2	90/103	0.86 (0.57–1.30)
	Quartile 3	85/106	0.78 (0.52–1.19)
	Quartile 4	88/129	0.67 (0.45–1.01)
C/T	Quartile 1	141/121	1.00	0.01
	Quartile 2	135/131	0.84 (0.59–1.19)
	Quartile 3	133/130	0.84 (0.59–1.19)
	Quartile 4	106/142	0.60 (0.42–0.86)
T/T	Quartile 1	58/35	1.00	<0.0001
	Quartile 2	55/42	0.73 (0.40–1.33)
	Quartile 3	39/61	0.33 (0.18–0.60)
	Quartile 4	35/54	0.37 (0.20–0.69)
MTHFR 1298A>C (rs1801131)
A/A	Quartile 1	34/34	1.00	0.13
	Quartile 2	35/32	1.07 (0.54–2.15)
	Quartile 3	38/30	1.29 (0.64–2.58)
	Quartile 4	31/54	0.55 (0.28–1.07)
A/C	Quartile 1	131/125	1.00	0.08
	Quartile 2	121/118	0.91 (0.63–1.31)
	Quartile 3	110/121	0.86 (0.59–1.24)
	Quartile 4	103/134	0.73 (0.50–1.05)
C/C	Quartile 1	137/92	1.00	<0.0001
	Quartile 2	121/117	0.68 (0.47–1.00)
	Quartile 3	112/140	0.48 (0.33–0.70)
	Quartile 4	96/133	0.44 (0.30–0.65)
MTR 2756A>G (rs1805087)
A/A	Quartile 1	193/148	1.00	<0.0001
	Quartile 2	171/155	0.86 (0.63–1.17)
	Quartile 3	161/181	0.68 (0.50–0.92)
	Quartile 4	154/194	0.59 (0.43–0.81)
A/G	Quartile 1	99/95	1.00	0.01
	Quartile 2	95/96	0.86 (0.57–1.29)
	Quartile 3	88/104	0.76 (0.51–1.15)
	Quartile 4	67/108	0.59 (0.39–0.91)
G/G	Quartile 1	11/11	1.00	0.25
	Quartile 2	11/22	0.39 (0.12–1.23)
	Quartile 3	11/12	0.63 (0.19–2.12)
	Quartile 4	11/23	0.37 (0.12–1.18)

The P values (<0.05), which are statistically significant, are presented in bold. The odds ratios (ORs) (95 % confidence interval (CI)) which correspond to the statistically significant P values are also presented in bold
^aPCA-derived Mediterranean dietary pattern with high loadings of vegetables, fruit, legumes and fish, thus closely resembling the Mediterranean diet
^bQuartiles of adherence to PCA-derived Mediterranean dietary pattern, with subjects in quartile 1, showing the lowest consumption of vegetables, fruit, legumes and fish, and thus, lowest adherence to this dietary pattern and with subjects in quartile 4, showing the highest consumption of the same four food groups and therefore highest adherence to this dietary pattern
^cAdjusted for menopausal status, age and for the other PCA-derived dietary components (Pattern 1, 2 and 3)
^d P for trend within a specific SNP genotype across quartiles of adherence to the PCA-derived Mediterranean dietary pattern

ISSN: 1865-3499