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Table 3 Concentrations of serum folate and p-tHcy after folic acid supplementation according to the genotypes

From: Effect of genetic polymorphisms involved in folate metabolism on the concentration of serum folate and plasma total homocysteine (p-tHcy) in healthy subjects after short-term folic acid supplementation: a randomized, double blind, crossover study

 

Serum folate over baseline and after supplementation

p-tHcy over baseline and after supplementation

 

Allele frequency

Baseline

After supplementation

p value

Baseline

After supplementation

p value

MTHFR-677C>T

       

CC (n = 40)

C:0.67

18.0 ± 6.2

49.5 ± 40.1*

<0.0001

7.3 ± 1.9

7.0 ± 1.4**

0.22

CT (n = 43)

T:0.33

16.4 ± 5.8

34.6 ± 20.0

<0.0001

8.7 ± 2.3

7.8 ± 2.0

<0.0001

TT (n = 8)

 

17.8 ± 9.0

26.0 ± 9.4

0.005

12.6 ± 8.9

11.7 ± 7.6

0.32

MTHFR-1298A>C

       

AA (n = 46)

A:0.69

17.9 ± 6.5

35.5 ± 19.3

<0.0001

8.9 ± 4.5

8.2 ± 3.9

0.01

AC (n = 34)

C:0.31

16.7 ± 6.3

43.2 ± 35.7

<0.0001

8.2 ± 2.0

7.5 ± 1.5

0.007

CC (n = 11)

 

15.7 ± 5.4

50.3 ± 48.8

0.0003

7.3 ± 1.7

7.0 ± 1.6

0.3

RFC1-80G>A

       

GG (n = 26)

G:51

16.6 ± 5.1

30.8 ± 11.4

<0.0001

8.1 ± 1.9

7.4 ± 1.4

0.04

GA (n = 41)

A:49

16.3 ± 6.0

41.6 ± 33.3

<0.0001

8.7 ± 4.6

8.0 ± 3.8

0.02

AA (n = 24)

 

19.4 ± 7.5

47.4 ± 37.6

<0.0001

8.3 ± 2.5

7.8 ± 2.4

0.02

MTHFD1-1958G>A

       

GG (n = 32)

G:0.58

16.9 ± 6.2

37.8 ± 29.5

<0.0001

8.3 ± 1.8

7.5 ± 1.4

0.3

GA (n = 41)

A:0.42

16.4 ± 4.6

41.0 ± 35.0

<0.0001

8.6 ± 4.7

8.1 ± 4.0

0.02

AA (n = 18)

 

19.7 ± 9.0

42.0 ± 21.2

<0.0001

8.3 ± 2.5

7.6 ± 2.2

0.003

MTR-2756A>G

       

AA (n = 54)

A:0.78

17.3 ± 6.5

43.2 ± 35.2

<0.0001

8.3 ± 2.3

7.7 ± 1.9

0.008

AG (n = 34)

G:0.22

17.4 ± 6.1

35.4 ± 22.1

<0.0001

8.5 ± 4.9

7.7 ± 4.2

0.005

GG (n = 3)

 

15.0 ± 4.1

35.1 ± 15.8

0.02

9.7 ± 5.5

9.6 ± 5.0

0.9

DHFR-19del

       

WW (n = 34)

W:0.59

16.3 ± 5.2

42.3 ± 35.6

<0.0001

8.4 ± 2.2

7.7 ± 1.7

0.06

WD (n = 36)

D:0.41

17.7 ± 6.9

34.0 ± 22.0

<0.0001

8.6 ± 4.9

8.1 ± 4.4

0.14

DD (n = 21)

 

18.0 ± 6.8

46.3 ± 33.5

<0.0001

8.1 ± 2.3

7.4 ± 1.7

0.0006

TS

       

2R2R (n = 22)

2R:0.50

18.3 ± 8.4

37.2 ± 26.4

<0.0001

8.2 ± 2.7

7.5 ± 2.1

0.25

2R3R (n = 46)

3R:0.50

17.4 ± 5.5

40.1 ± 30.9

<0.0001

8.8 ± 4.5

8.1 ± 3.9

0.002

3R3R (n = 23)

 

15.9 ± 5.3

42.7 ± 34.6

<0.0001

7.9 ± 1.5

7.4 ± 1.6

0.03

  1. Data are presented as mean ± SD
  2. * p = 0.01, and ** p = 0.0006 ANOVA test. The genotype distribution for each polymorphism was tested for possible deviation from HWE
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Genes & Nutrition

ISSN: 1865-3499

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