Skip to main content

Table 6 Concentrations of serum folate, serum vitamin B12, intake of B-vitamins and intake of protein according to the genotypes

From: Effect of genetic polymorphisms involved in folate metabolism on the concentration of serum folate and plasma total homocysteine (p-tHcy) in healthy subjects after short-term folic acid supplementation: a randomized, double blind, crossover study

 

Serum folate (nmol/L)

Folate intake (µg/day)

Serum vitamin B12 (pmol/L)

Vitamin B12 intake (µg/day)

Vitamin B2 intake (µg/day)

Vitamin B6 intake (mg/day)

p-tHcy (µmol/L)

Protein intake (g/day)

All subjects

17.3 ± 6.0 (16.5)

286 ± 97 (282)

316 ± 134 (286)

6.8 ± 3.5 (6.2)

2.0 ± 0.9 (1.7)

1.7 ± 0.5 (1.7)

8.2 ± 3.2 (7.7)

96.1 ± 26.8 (90.5)

MTHFR-677C>T

        

CC (n = 41)

18.3 ± 5.9 (17.2)

289 ± 106 (288)

275 ± 79 (261)*

7.2 ± 4.3 (5.9)

2.0 ± 0.8 (1.8)

1.7 ± 0.5 (1.7)

7.2 ± 1.7 (7.1)*

95.6 ± 23.0 (91.8)

CT (n = 46)

16.3 ± 6.0 (15.3)

282 ± 95 (273)

324 ± 127 (311)

6.5 ± 2.7 (6.0)

2.0 ± 0.9 (1.7)

1.7 ± 0.6 (1.7)

8.5 ± 2.1 (8.3)

97.4 ± 31.0 (89.6)

TT (n = 9)

17.6 ± 6.9 (14.8)

292 ± 70 (291)

459 ± 244 (336)

7.3 ± 3.1 (6.6)

1.8 ± 0.7 (1.6)

1.7 ± 0.3 (1.5)

11.5 ± 8.7 (8.5)

90.9 ± 18.3 (87.0)

MTHFR-1298A>C

        

AA (n = 47)

17.9 ± 6.4 (16.6)

274 ± 89 (267)

329 ± 148 (318)

6.5 ± 2.8 (6.0)*

1.8 ± 0.9 (1.7)*

1.6 ± 0.5 (1.6)

8.3 ± 4.1 (7.5)

91.5 ± 24.5 (87)*

AC (n = 38)

16.7 ± 6.1 (16.1)

305 ± 105 (292)

305 ± 124 (275)

7.6 ± 4.3 (7.1)

2.2 ± 0.9 (2.1)

1.9 ± 0.6 (1.8)

8.3 ± 2.1 (8.1)

106.0 ± 29.6 (102)

CC (n = 11)

16.5 ± 4.8 (16.3)

269 ± 100 (276)

301 ± 106 (273)

5.4 ± 1.5 (5.5)

1.6 ± 0.3 (1.6)

1.6 ± 0.4 (1.5)

7.1 ± 1.6 (6.8)

81.5 ± 12.2 (82.1)

RFC1-80G>A

        

GG (n = 27)

16.3 ± 5.1 (15.2)

291 ± 114 (272)

275 ± 79 (257)

7.1 ± 5.3 (5.8)

1.9 ± 0.9 (1.7)

1.7 ± 0.6 (1.6)

7.8 ± 1.5 (8.1)

93.2 ± 29.0 (85.5)

GA (n = 44)

17.0 ± 6.0 (16.8)

278 ± 93 (284)

345 ± 148 (299)

6.5 ± 2.3 (6.1)

1.9 ± 0.7 (1.7)

1.7 ± 0.5 (1.6)

8.5 ± 4.3 (7.6)

95.9 ± 22.8 (90.4)

AA (n = 25)

18.8 ± 7.1 (16.6)

296 ± 89 (285)

310 ± 147 (282)

7.2 ± 2.9 (6.4)

2.1 ± 1.1 (1.7)

1.8 ± 0.5 (1.8)

7.9 ± 2.2 (7.6)

99.6 ± 32.0 (93.8)

MTHFD1-1958G>A

        

GG (n = 34)

16.9 ± 6.4 (16.7)

293 ± 90 (288)

329 ± 159 (299)

6.4 ± 1.8 (6.5)

2.0 ± 0.7 (1.9)

1.7 ± 0.5 (1.7)

8.2 ± 2.0 (7.7)

97.4 ± 25.7 (88.8)

GA (n = 43)

16.6 ± 4.8 (15.7)

290 ± 108 (288)

308 ± 107 (282)

7.2 ± 4.4 (6.2)

2.0 ± 1.0 (1.7)

1.7 ± 0.6 (1.7)

8.4 ± 4.3 (7.5)

97.4 ± 29.6 (95.5)

AA (n = 19)

19.5 ± 7.7 (18.3)

264 ± 88 (237)

312 ± 144 (277)

7.0 ± 3.6 (5.7)

1.8 ± 0.7 (1.7)

1.7 ± 0.5 (1.5)

7.6 ± 1.8 (7.7)

90.8 ± 22.9 (82.8)

MTR-2756A>G

        

AA (n = 57)

17.5 ± 6.3 (16.5)

287 ± 101 (267)

322 ± 145 (294)

7.0 ± 4.0 (6.2)

2.0 ± 0.9 (1.7)

1.8 ± 0.6 (1.7)

8.0 ± 1.9 (8.1)

98.5 ± 26.8 (92.4)

AG (n = 36)

17.1 ± 5.9 (16.6)

292 ± 92 (288)

304 ± 110 (278)

6.9 ± 2.5 (6.3)

2.0 ± 0.7 (1.8)

1.7 ± 0.5 (1.7)

8.4 ± 4.7 (7.3)

94.4 ± 26.8 (91.8)

GG (n = 3)

15.3 ± 3.6 (13.2)

201 ± 61 (208)

358 ± 198 (267)

6.9 ± 2.5 (6.3)

1.1 ± 0.2 (1.0)

1.1 ± 0.4 (0.9)

9.3 ± 4.1 (7.2)

68.8 ± 11.5 (73.5)

DHFR-19del

        

WW (n = 38)

16.4 ± 5.2 (15.7)

286 ± 92 (291)

322 ± 147 (278)

5.6 ± 1.7 (5.5)*

1.8 ± 0.7 (1.7)

1.7 ± 0.6 (1.7)

8.1 ± 1.9 (8.2)

92.4 ± 25.4 (86.7)

WD (n = 37)

17.7 ± 6.4 (17.0)

288 ± 104 (284)

311 ± 130 (285)

8.2 ± 4.6 (7.1)

2.1 ± 1.0 (1.7)

1.7 ± 0.5 (1.7)

8.3 ± 4.7 (7.4)

98.1 ± 26.6 (91.3)

DD (n = 21)

18.1 ± 6.9 (16.8)

281 ± 99 (264)

314 ± 119 (329)

6.6 ± 2.5 (5.8)

1.9 ± 0.8 (1.9)

1.7 ± 0.5 (1.7)

8.0 ± 2.2 (8.1)

99.1 ± 29.9 (96.2)

TS

        

2R2R (n = 24)

18.1 ± 7.5 (17.2)

301 ± 86 (297)

341 ± 157 (329)

8.1 ± 5.5 (6.2)

2.1 ± 0.9 (1.7)

1.8 ± 0.4 (1.7)

7.8 ± 2.5 (7.6)

102.0 ± 26.2 (95.4)

2R3R (n = 49)

17.5 ± 5.6 (16.7)

283 ± 99 (273)

316 ± 142 (273)

6.2 ± 2.1 (5.8)

1.9 ± 0.7 (1.7)

1.7 ± 0.6 (1.7)

8.6 ± 4.1 (7.6)

94.2 ± 25.9 (88.8)

3R3R (n = 24)

15.9 ± 5.6 (14.2)

277 ± 107 (271)

293 ± 86 (290)

6.9 ± 2.8 (6.9)

2.0 ± 1.0 (1.7)

1.6 ± 0.5 (1.5)

7.7 ± 1.3 (7.9)

94.0 ± 29.5 (87.6)

  1. Data are presented as mean ± SD and median in parentheses
  2. * Significant difference between the groups (p < 0.05)
Back to article page

Genes & Nutrition

ISSN: 1865-3499

Contact us