Fig. 2

CSS-induced increase of locomotor activity in subordinate db/db mice. a Increased average daily dark (D, filled circles) and light (L, empty circles) phase values during the stress phase vs baseline. b Animals experiencing the social defeat encounter (indicated by the red asterisks) daily between ZT3.5 (0830 hours) and ZT4.5 (0930 hours) exhibited a disrupted pattern of activity compared to baseline. c Quantification of CSS-induced increase in subordinate mice activity during both the light and the dark phase of the stress compared to baseline values. (N = 11). *p < 0.05 versus corresponding phase in baseline