Table 2 Metabolic and neuroendocrine effect induced by chronic subordination stress in db/db and wild-type mice fed high-fat diet
From: Chronic stress aggravates glucose intolerance in leptin receptor-deficient (db/db) mice
| Â | Wild type* | db/db |
|---|---|---|
Physiology and Behavior | ||
Food intake | ↑ | ↑ |
Body weight gain | ↑ | = |
Fat mass | ↑ | = |
Lean mass | Na | = |
Stress-induced home cage activity | ↓ | ↑ |
Glucose homeostasis | ||
Random-fed glucose | = | ↑ |
Fasting Glucose | ↑ | = |
Glucose intolerance in the GTT | ↑ | ↑ |
Hormones # | ||
Corticosterone–fed state | ↑ | Na |
Corticosterone | = | ↓ |
Insulin | ↑ | = |
TNF-alpha | Na | ↑ |
Il-6 | ↑ | ↑ |
Total ghrelin | ↓ | = |
GLP-1 | Na | = |
Glucagon | Na | = |
Leptin | ↑ | = |
Resistin | Na | = |
Adiponectin | ↓ | Na |
Amylin | Na | = |
MCP-1 | Na | = |