Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice

Table 1 Hepatic gene expression (RT-qPCR)

Gene symbol	HF	HF + Q	HF + H	HF + E	HF + Ap	HF + An
Gene symbol	versus NF	versus HF
Lipid omega-oxidation
Acot3	2.67^##	1.07	−1.07	1.07	1.16	1.05
Cyp4a10	2.06^##	−1.09	1.15	1.05	−1.12	1.05
Cyp4a14	2.39^###	1.11	1.23	1.09	1.06	1.04
Por	1.34	1.08	1.14	1.12	1.07	1.02
Lipid metabolism
Acacb	−1.76^##	1.07	1.01	1.11	−1.10	1.12
Fasn	−1.10	1.10	1.05	1.17	−1.05	1.02
Cpt1a	1.25	−1.06	1.05	−1.02	−1.12	−1.01
Ppara	1.29	−1.07	1.09	1.02	−1.09	1.01
Ppargc1a	−1.51^##	−1.06	1.05	1.10	1.18	−1.09
CAR target
Cyp2b9	40.60^###	−8.22***	−8.02***	−5.85**	−6.33**	−9.05***

Data are presented as mean fold change of HF versus NF and HF + flavonoids versus HF
NF, normal-fat diet; HF, high-fat diet; HF supplemented with quercetin, HF + Q; hesperetin, HF + H; epicatechin, HF + E; apigenin, HF + Ap; anthocyanins, HF + An
^##Indicates significant difference of HF to NF (p < 0.01), ^### p < 0.001, ** indicates a significant difference of HF + flavonoid to HF (p < 0.01), *** p < 0.001

ISSN: 1865-3499