Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice

Table 2 Gene expression in white adipose tissue

Gene symbol	Function	HF	HF + Q	HF + H
Gene symbol	Function	versus NF	versus HF
Fasn	Fatty acids synthesis	−4.19^###	1.05	−1.18
Cpt1α	Fatty acid beta-oxidation	1.83^###	−1.32	−1.22
Ppargc1α	mitochondrial biogenesis	−2.13^###	1.10	−1.10
Lipe	Lipolysis	−1.10	1.02	−1.05
Pnpla2	Lipolysis	−1.66^###	1.27	1.14
Lep	Leptin	5.80^###	−1.70***	−1.52**
Pparg	Adipocyte differentiation	−1.48	−1.00	−1.14
Clmp	Adipocyte differentiation	1.25	−1.13	−1.20

Data are presented as mean fold change of HF versus NF and HF + flavonoids versus HF
NF, normal-fat diet; HF, high-fat diet; HF + Q, HF supplemented with quercetin; HF + H, hesperetin
^###Indicates significant difference of HF to NF (p < 0.001), ** indicates a significant difference of HF + flavonoid to HF (p < 0.01), *** p < 0.001

ISSN: 1865-3499