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Table 2 Global DNA methylation of the DNA in the F0 generation measured from peripheral blood leukocytes at different time points

From: The diet-induced metabolic syndrome is accompanied by whole-genome epigenetic changes

 

12 (weeks)

24 (weeks)

36 (weeks)

CON diet

HFD

CON diet

HFD

CON diet

HFD

STZ

Male

n

3

3

4

3

3

5

4

% 5-mC in blood

2.14 ± 0.10

1.69 ± 0.06*

2.27 ± 0.39

1.77 ± 0.21

2.33 ± 0.23

1.85 ± 0.18

2.89 ± 0.07

Female

n

4

6

4

5

3

5

% 5-mC in blood

1.27 ± 0.08

1.48 ± 0.05

1.34 ± 0.04

1.52 ± 0.11

1.53 ± 0.13

1.68 ± 0.18

–

  1. All results were expressed as mean ± SEM
  2. CON diet control diet, HFD high-fat/high-fructose diet, STZ streptozotocin, 5-mC 5-methylcytosine
  3. Mean values significantly differ from the control, * P < 0.05, tested by Dunnett’s test
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Genes & Nutrition

ISSN: 1865-3499

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