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Table 4 Global DNA methylation of the DNA in the F1 generation measured from peripheral blood leukocytes at 12 weeks and 24 weeks

From: The diet-induced metabolic syndrome is accompanied by whole-genome epigenetic changes

 

12 (weeks)

24 (weeks)

F0 CON diet

CON diet

F1 HFD

F0 CON diet

CON diet

F1 HFD

Male

n

3

2

2

4

4

4

% 5-mC in blood

2.14 ± 0.10

1.87 ± 0.16

2.14 ± 0.51

2.27 ± 0.39

2.14 ± 0.21

2.30 ± 0.32

Female

n

4

1

3

4

2

2

% 5-mC in blood

1.27 ± 0.08

1.64

1.39 ± 0.02

1.34 ± 0.04

1.33 ± 0.01

1.32 ± 0.04

  1. All results were expressed as mean ± SEM
  2. F 0 CON diet, parental group with control diet; F 1 , offspring generation; CON diet control diet; HFD high-fat/high-fructose diet; 5-mC 5-methylcytosine
  3. Mean values significantly differ from the control, * P < 0.05, tested by Dunnett’s test
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Genes & Nutrition

ISSN: 1865-3499

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