A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population

Genes & Nutrition

Table 2 Association results of lead SNPs for various plasma polyunsaturated fatty acids and delta-6 desaturase activity (D6D) detected at genome-wide levels (p value <5 × 10⁻⁸) in SCHS

Outcome variable	Lead SNP	Test allele	TAF	Chr	Position	β	SE	p value	Q_{p value}	Variance explained by lead SNP (%)	r ² with index FADS1 SNP (rs174757)
ALA	rs509360	G	0.673	11	61548559	0.1087	0.0195	2.51 × 10⁻⁸	0.9499	2.0	0.972
LA	rs174547	T	0.338	11	61570783	−0.0480	0.0056	1.12 × 10⁻¹⁶	0.6123	5.3	NA
GLA	rs174546	T	0.662	11	61569830	−0.5227	0.0187	5.18 × 10⁻¹⁷¹	0.5720	36.5	1.000
GLA adjusted for LA	rs174546	T	0.662	11	61569830	−0.5312	0.0183	1.72 × 10⁻¹⁷⁵	0.5720	36.5
DGLA	rs174548	G	0.649	11	61571348	−0.1789	0.0152	6.91 × 10⁻³¹	0.6884	8.4	0.973
DGLA adjusted for GLA	rs174548	G	0.649	11	61571348	0.1282	0.0129	5.42 × 10⁻²²	0.6884	7.9
AA	rs174577	C	0.335	11	61604814	0.1542	0.0088	4.22 × 10⁻⁶⁸	0.2448	18.0	0.994
AA adjusted for DGLA	rs174577	C	0.335	11	61604814	0.2090	0.0118	1.58 × 10⁻⁶⁸	0.2448	18.6
D6D	rs174548	G	0.649	11	61571348	−0.2384	0.0181	2.26 × 10⁻³⁸	0.7245	9.1	0.973

Association results are from meta-analysis of MI cases and control datasets (N = 1361). The index FADS1 SNP (rs174757) was identified in previous GWAS studies for the same FA subtypes in Lemaitre et al. (2011) and Guan et al. (2014)
Lead SNP: strongest SNP association in SCHS meta-analysis; TAF: test allele frequency; Q_{p value}: Cochran’s Q heterogeneity measure

ISSN: 1865-3499