A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population

Dorajoo, Rajkumar; Sun, Ye; Han, Yi; Ke, Tingjing; Burger, Ayala; Chang, Xuling; Low, Hui Qi; Guan, Weihua; Lemaitre, Rozenn N.; Khor, Chiea-Chuen; Yuan, Jian-Min; Koh, Woon-Puay; Ong, Choon Nam; Tai, E. Shyong; Liu, Jianjun; van Dam, Rob M.; Heng, Chew-Kiat; Friedlander, Yechiel

doi:10.1007/s12263-015-0502-2

Genes & Nutrition

Table 3 The associations between reported n-3 and n-6 FA subtype index SNPs (Lemaitre et al. 2011; Guan et al. 2014) and n-3 fatty acids (ALA, EPA and DHA) in the meta-analysis data of SCHS

From: A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population

Index SNPs from reported GWAS studies for omega-3 and omega-6 fatty acid subtypes (Lemaitre et al. 2011; Guan et al. 2014)					SCHS meta-analysis (N = 1361)
					Power (%)	Comment	Test allele	TAF	ALA			EPA			DHA
Trait	SNP	Chr	Position	Reported Gene	Power (%)	Comment	Test allele	TAF	β	SE	p value	β	SE	p value	β	SE	p value
ALA	rs174547	11	61570783	FADS1	50.42	Typed	T	0.3382	−0.100	0.019	1.88 × 10 ⁻⁷*	0.059	0.019	0.0017	0.007	0.022	0.7646
EPA	rs3798713	6	11116608	ELOVL2	40.39	Imp	G	0.278	0.020	0.019	0.3086	0.004	0.019	0.8182	0.004	0.022	0.8456
	rs174538	11	61560081	FADS1	99.99	Typed	G	0.3419	−0.099	0.019	2.15 × 10 ⁻⁷	0.061	0.019	0.0011*	0.012	0.021	0.5866
	rs174535	11	61551356	FADS1	99.99	Typed	T	0.3324	−0.103	0.019	9.21 × 10 ⁻⁸	0.060	0.019	0.0016*	0.007	0.022	0.7625
DPA	rs780094	2	27741237	GCKR	NA	Typed	T	0.4535	0.027	0.017	0.1239	0.028	0.017	0.0983	0.062	0.020	0.0019
	rs3734398	6	10982973	ELOVL2	NA	Typed	T	0.0669	−0.006	0.035	0.8640	−0.027	0.034	0.4315	−0.001	0.040	0.9738
	rs174547	11	61570783	FADS1	NA	Imp	T	0.3382	−0.100	0.019	1.88 × 10 ⁻⁷	0.059	0.019	0.0017	0.007	0.022	0.7646
DHA	rs2236212	6	11103001	ELOVL2	52.23	Imp	G	0.282	−0.004	0.018	0.8396	0.008	0.018	0.6618	0.002	0.022	0.9392
LA	rs10740118	10	64771213	JMJD1C	15.43	Imp	G	0.7048	0.005	0.019	0.7824	0.016	0.019	0.405	0.048	0.022	0.0321
	rs174547	11	61570783	FADS1	99.99	Typed	T	0.3382	−0.100	0.019	1.88 × 10 ⁻⁷	0.059	0.019	0.0017	0.007	0.022	0.7646
	rs16966952	16	15135943	NTAN1/PDXDC1	32.36	Typed	G	0.6054	−0.008	0.018	0.6452	−0.005	0.017	0.7866	−0.016	0.020	0.4231
GLA	rs174547	11	61570783	FADS1	58.38	Typed	T	0.3382	−0.100	0.019	1.88 × 10 ⁻⁷	0.059	0.019	0.0017	0.007	0.022	0.7646
GLA	rs16966952	16	15135943	NTAN1/PDXDC1	12.05	Typed	G	0.6054	−0.008	0.018	0.6452	−0.005	0.017	0.7866	−0.016	0.020	0.4231
DGLA	rs174547	11	61570783	FADS1	99.99	Typed	T	0.3382	−0.100	0.019	1.88 × 10 ⁻⁷	0.059	0.019	0.0017	0.007	0.022	0.7646
DGLA	rs16966952	16	15135943	NTAN1/PDXDC1	99.99	Typed	G	0.6054	−0.008	0.018	0.6452	−0.005	0.017	0.7866	−0.016	0.020	0.4231
AA	rs174547	11	61570783	FADS1	99.99	Typed	T	0.3382	−0.100	0.019	1.88 × 10 ⁻⁷	0.059	0.019	0.0017	0.007	0.022	0.7646
AA	rs16966952	16	15135943	NTAN1/PDXDC1	60.62	Typed	G	0.6054	−0.008	0.018	0.6452	−0.005	0.017	0.7866	−0.016	0.020	0.4231
Adrenic acid	rs174547	11	61570783	FADS1	NA	Typed	T	0.3382	−0.100	0.019	1.88 × 10 ⁻⁷	0.059	0.019	0.0017	0.007	0.022	0.7646
Adrenic acid	rs3134950	6	32235455	PPT2	NA	Imp	C	0.4111	−0.036	0.018	0.0493	−0.013	0.018	0.4801	0.007	0.021	0.7354

Significant (p value <0.05) associations indicated in bold
Power: indicates power in the SCHS study to detect reported associations at these SNPs given reported effect estimates (Yokoyama et al. 2007; Wang et al. 2006) and MAF of SCHS dataset; NA: power not calculated for previously reported traits that were not measured in SCHS; TAF: test allele frequency
* Indicates significant association for the same n-3 trait in the SCHS data

Back to article page

ISSN: 1865-3499

Contact us

General enquiries: journalsubmissions@springernature.com