Fig. 2

Schematic representation of the case study workflow. Transcriptomic data from brain tissue of treatment groups (caloric restriction, low-dose resveratrol supplementation and control diet) from young and aged mice were analyzed using a novel approach enabling the identification of transcriptional signature characterizing each group. Network analysis was then performed using Netwalker method and the mouse-specific BioGRID PPI database. Finally, the functional enrichments of the genes obtained from the network analysis were characterized by investigating over-represented gene ontology biological processes and pathways