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Table 1 Association between fiber intake and type 2 diabetes and related traits in MDCS

From: Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes

  

Quintiles of fiber intake

  
 

Total

Q1

Q2

Q3

Q4

Q5

Î’eta (SE) or HR (CI)

P valuea

N

26,905

5381

5381

5381

5381

5381

  

Sex (% males)

10,429 (39 %)

3039 (57 %)

2426 (45 %)

2062 (38 %)

1635 (30 %)

1267 (24 %)

  

Age (years)

58.0 ± 7.6

57.4 ± 7.5

57.7 ± 7.7

58.2 ± 7.7

58.3 ± 7.7

58.3 ± 7.5

  

Incident type 2 diabetes

3132 (10.6 %)

666 (11.3 %)

650 (11.0 %)

670 (11.4 %)

564 (9.56 %)

582 (10.9 %)

0.98 (0.96–1.01)

0.17

BMI (kg/m2)

25.6 ± 3.9

25.5 ± 3.9

25.6 ± 3.8

25.8 ± 3.9

25.7 ± 3.9

25.5 ± 4.0

0.02 (0.02)

0.22

FPG (mmol/L)b

5.64 ± 0.82

5.81 ± 1.04

5.68 ± 0.78

5.63 ± 0.79

5.58 ± 0.73

5.54 ± 0.72

−0.03 (0.008)

0.0001

FPI (pmol/L)b

46.5 ± 46.2

50.7 ± 43.5

46.2 ± 33.6

47.5 ± 50.5

45.1 ± 59.3

43.9 ± 38.9

−0.95 (0.48)

6 × 10−07

HOMA-IRb

1.60 ± 1.22

1.75 ± 1.32

1.64 ± 1.06

1.65 ± 1.62

1.53 ± 1.04

1.48 ± 1.00

−0.06 (0.01)

6 × 10−09

HbA1C (%)b

4.81 ± 0.49

4.89 ± 0.58

4.82 ± 0.45

4.82 ± 0.53

4.80 ± 0.43

4.76 ± 0.47

−0.02 (0.005)

0.00002

HbA1C (mmol/mol)b

39.7 ± 5.00

40.5 ± 5.88

39.8 ± 4.56

39.8 ± 5.36

39.5 ± 4.38

39.2 ± 4.75

−0.22 (0.05)

0.00002

Fiber (g/1000 Kcal)

9.03 ± 2.72

5.77 ± 0.81

7.47 ± 0.36

8.69 ± 0.36

10.09 ± 0.48

13.13 ± 2.19

  
  1. Data are means ± SD unless otherwise stated. Number of individuals included in MDCS cohort, n = 26,905
  2. HR hazard ratio, BMI body mass index, FPG fasting plasma glucose, FPI fasting plasma insulin, HOMA-IR homeostatic model assessment for insulin resistance, HbA 1C glycated hemoglobin
  3. aAdjusted for age, sex, BMI, total energy intake, dietary assessment method, season, leisure-time physical activity, smoking, alcohol intake, and education where appropriate
  4. bData available only for the MDC-CC, n = 5499